Side effects with omeprazole/Prilosec use

Posted by blueorca @blueorca, May 5, 2018

i am an 18-year user of daily OTC Prilosec. It does a perfect job of controlling my GERD but I am constantly battling side effects of nutritional deficiencies in iron, B-12, magnesium, etc. For example, my hair is extremely thin and loss of energy is a constant problem. I am looking for specific help in knowing which supplements to take for this and in what doses and formats and on what schedule. All the nutritionists I've found locally are not well-versed in Prilosec use. Is there a medical provider out there who specializes in this? And would they be willing to work with me long distance?

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Profile picture for dmuth2 @dmuth2

I’m in the process of weaning myself off of Prilosec, I’ve been a user for over 15 years constantly daily of 20 mg. I’m going to 10 mg for two weeks and then 5 mg for 2 and in 4 weeks hope to be at zero. I’ve tried this before with no success as the acid production comes back with extreme vengeance. The reason I’m quitting is my new doctor has strongly suggested I do this as research is suggesting possible harmful side effects. It’s day three and I’m feeling discomfort and frantic nerves.

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It may be helpful for you to consult a nutritionist with knowledge in treating healthy eating for gut issues as you taper off the PPI. As you taper off and are totally off, symptoms will return as it did for me. It’s critical to make dietary changes changes to support good gut health.
Here’s what was recommended for me along with some supplements and I no longer have GERD or indigestion:
*Eliminate gluten products - gluten free bread, almond flour crackers, etc. it doesn’t matter if you’re not gluten intolerant and don’t have Celiac disease.
*Reduce sugars - eat low sugar fruit(strawberries, blueberries, raspberries), low sugar vegetables, use only stevia as a sweetener
*Consume fermented foods - Kefir, sauerkraut if you like it, pickles but only from the refrigerated section, kombucha, kimchi.
*Diary - it is the fat that can be difficult to digest. I switched to almond milk, yogurt with A2 protein ( makes it digestible ) or try sheep or goat milk products.
*Eliminate highly processed foods as they have too many chemicals.
Best to you as you go through this. PPI’s can have serious side effects. I was told by my GI to never take again due to side effect.

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Profile picture for gigi4 @gigi4

It may be helpful for you to consult a nutritionist with knowledge in treating healthy eating for gut issues as you taper off the PPI. As you taper off and are totally off, symptoms will return as it did for me. It’s critical to make dietary changes changes to support good gut health.
Here’s what was recommended for me along with some supplements and I no longer have GERD or indigestion:
*Eliminate gluten products - gluten free bread, almond flour crackers, etc. it doesn’t matter if you’re not gluten intolerant and don’t have Celiac disease.
*Reduce sugars - eat low sugar fruit(strawberries, blueberries, raspberries), low sugar vegetables, use only stevia as a sweetener
*Consume fermented foods - Kefir, sauerkraut if you like it, pickles but only from the refrigerated section, kombucha, kimchi.
*Diary - it is the fat that can be difficult to digest. I switched to almond milk, yogurt with A2 protein ( makes it digestible ) or try sheep or goat milk products.
*Eliminate highly processed foods as they have too many chemicals.
Best to you as you go through this. PPI’s can have serious side effects. I was told by my GI to never take again due to side effect.

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Thank you! Very helpful if you have any other suggestions on diet please pass along.

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Profile picture for Bonnie @nightngale1998

Hi there: Has anyone had success in weaning off of Omeprazole? I take it for GERD. Thank you in advance!

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I have found if I stick to a mostly vegan diet that my GERD is a lot better. Not perfect but much better. I also have really reduced caffeine, sugar and white flour carbs - the sugar and white flour was easier to give up then reducing my morning coffee to just 1 smaller cup but it was well worth it. I do not have dairy or red meat but will occasionally have chicken or fish but I get it from local place not the grocery store/factory farmed stuff. I now eat fruit for dessert and only indulge once in a while and this all hasn't been hard at all because I felt better right away. I used to have to take 2-3 pantoprozole to control my issues and now I'm down to 1 with hopes of going off that completely by my next appointment.

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Profile picture for gigi4 @gigi4

It may be helpful for you to consult a nutritionist with knowledge in treating healthy eating for gut issues as you taper off the PPI. As you taper off and are totally off, symptoms will return as it did for me. It’s critical to make dietary changes changes to support good gut health.
Here’s what was recommended for me along with some supplements and I no longer have GERD or indigestion:
*Eliminate gluten products - gluten free bread, almond flour crackers, etc. it doesn’t matter if you’re not gluten intolerant and don’t have Celiac disease.
*Reduce sugars - eat low sugar fruit(strawberries, blueberries, raspberries), low sugar vegetables, use only stevia as a sweetener
*Consume fermented foods - Kefir, sauerkraut if you like it, pickles but only from the refrigerated section, kombucha, kimchi.
*Diary - it is the fat that can be difficult to digest. I switched to almond milk, yogurt with A2 protein ( makes it digestible ) or try sheep or goat milk products.
*Eliminate highly processed foods as they have too many chemicals.
Best to you as you go through this. PPI’s can have serious side effects. I was told by my GI to never take again due to side effect.

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Hi ggi4 - Would you elaborate what "serious side effects" your GI doctor said is the reason to never take PPI's again? Thanks.

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Profile picture for fdixon63 @fdixon63

Hi ggi4 - Would you elaborate what "serious side effects" your GI doctor said is the reason to never take PPI's again? Thanks.

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In my case, my digestive tract cells were hypertrophic, meaning enlarged and not good. PPI's in general from what I learned can cause a variety of ill health effects - fractures, pneumonia risk, risk of C.difficile and iron and B12 deficiency as well as possible cancers. I had been on the PPI for 6 months and was concerned about continuing to use it as I didn't feel much better. My doctor listened and contacted GI and scheduled an endoscopy. It was my 3rd endoscopy over the course of 7 years dealing with indigestion and one and off acid reflux.

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Profile picture for Lisa Stubert @lstubert

I have found if I stick to a mostly vegan diet that my GERD is a lot better. Not perfect but much better. I also have really reduced caffeine, sugar and white flour carbs - the sugar and white flour was easier to give up then reducing my morning coffee to just 1 smaller cup but it was well worth it. I do not have dairy or red meat but will occasionally have chicken or fish but I get it from local place not the grocery store/factory farmed stuff. I now eat fruit for dessert and only indulge once in a while and this all hasn't been hard at all because I felt better right away. I used to have to take 2-3 pantoprozole to control my issues and now I'm down to 1 with hopes of going off that completely by my next appointment.

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Lisa, I found a low acid coffee called Lifeboost that I like very much. It's the acid in coffee that can affect our gut. Lifeboost can be ordered online at lifeboost.com and also on Amazon. It comes in caffeinated or decaf, light, medium or dark roast and also flavors. I have both caffeinated and decaf and sometimes do half of each if I want less caffeine but still get a little boost.

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Profile picture for Bonnie @nightngale1998

Hi there: Has anyone had success in weaning off of Omeprazole? I take it for GERD. Thank you in advance!

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The side effects that frighten me the most with long term usage are dementia and Kidney disease. I have been on them for many years. When PPI's first came out, they were thought to be very safe, with no major side effects, until in recent years, after studies we were done contradicting that. I tried to quit them and became quite ill to the point where I just quit eating. Lost 20lb. as food made me frightened to even eat. My GI doc said that the studies were not very impressive, and I should probably restart, which I did. Now I appear to have this LPR. If I thought GERD was bad, this is even worse. I pray a lot.

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Profile picture for marlaxyz @marlaxyz

I hesitate to write this because i am absolutely not an expert and am an experiment of one. With that said I will tell you my experience.

i was on Prilosec (prescription) for years and then there were a series of events and I stopped taking it. Surprise. NO problem. Then I had an endoscopy (for other reasons) and asked the doctor if he thought I should be taking Prilosec and he said he saw no reason. So I have not gone back to it.

What I did do was adjust my diet and stop eating citrus, tomatoes, and other items - i actually forget now because it is all in the past. I DO eat yogurt, cottage cheese, other cheese (not cheddar) peanut butter, meat, cooked (and non cruciferous) vegetables, yams, berries, bananas, other stuff. . I have a whole list somewhere if you want it, just PM me. I created the list by trial and error - if something gave me GERD, out it went.

One take away I came to was the gastroenterologists do like to prescribe Prilosec. If you have something it will probably fix it. I have other problems but Prilosec is not fixing them, still the GI doctor wanted me to take the Prilosec. . All medicines have an affect on our kidneys and livers. I have a sense Prilosec is not a bad medicine any more than any other (I went back to the original research and found it not compelling) ..it is just that all medicines have problems.

BTW - that vinegar. Yikes. NEVER or as Jackie above called it - "acid"

Best to you and good luck-

Val

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I have a different issue altogether: I had my first endoscopy because of a slight sign of anemia. The GI doc said I had moderately severe reflux! I said, no I dont. He insisted I take protonix. After 8 mos and reading about side effects I tried to speak to him about discontinuing, or at least having another endoscopy to see if it changed anything. He asked me if I wanted to follow his advice or the internet!!! Holy moly he isnt my doctor any more…

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Profile picture for Father of sticky rice @fatherofstickyrice

10 years ago or so, I had severe symptoms of having food stuck in my esophagus and not being able to swallow or bring food back up. This put me in the hospital a few times until an endoscopy diagnosed me with a schatzki ring. My gastroenterologist nipped it in one or two places and prescribed omeprazole 20 mg once per day. This worked fine for years. My current primary care physician wants me to come off of this proton pump inhibitor (PPI) and use an H2 blocker instead. I agree. I tried about a 10-day transition alternating between the two medications and then went to the H2 blocker (Famotidine) for 3 months with no omeprazole. I had swallowing difficulty symptoms almost every meal. They were mild to severe ( inability to swallow or bring food back up for 20 minutes with a production of fluid [saliva?] which required spitting and some small amounts of food coming up). So, I went back on Omeprazole about a month ago. Now I have obtained a prescription both. I would like to try to wean myself off of the PPI and onto an H2 blocker again. Here is my plan:● Alternate omeprazole 20 mg /day early am with famotidine 20 mg before breakfast and dinner for 14 days. Then alternate with PPI every 3rd day for 14 days. Then alternate with PPI every 4th day for 14 days.Does anyone have any experience with this transition? Any suggestions.

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I have been reading the here about the long term side effects of omeprozole and am going to try to wean off. Suggestions? Thanks!

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Profile picture for dedhambeth @dedhambeth

I have been reading the here about the long term side effects of omeprozole and am going to try to wean off. Suggestions? Thanks!

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Hi there- My dad was put on omeprozole in the hospital and had a long stay at both the acute care hospital, then a rehab facility. I was dismayed to find he was on it long term too after reading about the side effects.

(Disclaimer: If you went on it after talking to your doctor, of course, might make sense to talk with them about it.)

I used this as a guide to come up with a plan; it’s from the VA:
https://www.va.gov/WHOLEHEALTHLIBRARY/tools/coming-off-a-proton-pump-inhibitor.asp
I’m not sure how long you’ve been taking the PPI, and that may affect how difficult it could be to get off it. My dad was on it a moderate amount of time, and he didn’t have trouble, thankfully.

He also took/takes a magnesium supplement, which you may want to consider, especially if you have symptoms related to magnesium deficiency (fatigue, leg cramps, nausea). PPIs have been found to inhibit absorption of magnesium and deficiency is more prevalent in older people. You can also be tested.

Basically we reduced the dose as slowly as we could reasonably cut the tablets down with a pill cutter. My dad is very sensitive to medications, so we’re used to having to taper and titrate slowly. I can’t remember the denominations we used, but most sources say it should take longer than two weeks to get off it.

I think it took us at least a month. He’d take a dose for a week, then lower again, and so on. Getting down to the end, we alternated every other day, then every three days until he was off it.

I believe it also helps to address lifestyle changes, like reducing or avoiding foods that tend to cause more acid while you’re getting used to being off the PPI, in my dad’s case it’s important for him to eat while being as upright as possible (he is recovering from a stroke), and doing breathing exercises.

Good luck. I agree and I feel it’s worth it to try to get off it. I feel like the consequences should be more well-known. The hospital that prescribed it didn’t even discuss it with us.

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