I have been using Lantanoprost for about five years. I get chills and fatigue too, but never suspected it might be caused by Lantanoprost. And yes, I was told not to miss a dose. How advanced is your glaucoma and how high is your pressure? My last pressure readings were 16 and 17. I have forgotten to use my drops a few times over the years. I don’t think it really increased or damaged my eyes. Be sure you consult with opthomolgists for answers before you stop using the drops.