I am presently on 100 mg of Plaquenil for newly diagnosed Lupus every other day, (it has helped greatly with my pain & inflammation with fibro too), but, the side effects are not good. I see my Rheumatologist soon. I too have had Fibro for 20+ years. I was blessed to have a doctor diagnose me with Fibro and run a sed rate to rule out other autoimmune issues. He knew his stuff about Fibro...before it was widely known about at the time. You are so right, a painless day is a rarity. I cannot take NSAIDS like Advil, Motrin, Aleve. I wish I could! I am not on any antidepressants nor am I taking any prescription pain meds. The Plaquenil has given me much relief...but, the side effects are not good as I said! I am so glad that Tramadol helps you. You are correct, if you overdo, you pay for it FOR DAYS! God Bless you & Happy 4th!