Hello @missbutterfly2be,

I see that you are a new member to the Parkinson's support group on Mayo Connect. Welcome!

I agree that most Parkinson's meds, including Amantadine, lead to fatigue and have other side effects as well. I've taken Amantadine for several years and I've worked with my neurologist to lower the dose until I could get the most benefits from it without as many side effects. Every person reacts to meds differently and that is important to realize.

I look forward to getting to know you. As you are new to the group, please share as you are comfortable doing so, a little about your journey with PD. For example, how long ago were you diagnosed? What are your most troubling symptoms right now?