Anyone taken Evenity (romosozumab) for Osteoporosis?

So glad to hear you are off to a positive start. Not unusual for back of arms to swell before the day is up. A bit uncomfortable sleeping on side, but for me it was gone by the morning. I’m a fan of behind the back of each arm.

Try the back of the arms. I’ve had shots at both UCLA & Penn Medicine - all injections done back of each arm.

My doc doesn't do CTX. It seems most endocrinologists don't do that kind of blood work. I believe P1NP is an indicator of bone building and CTX is a measure of bone turnover. But docs don't seem to use these,

Yes a break after one or possibly two Reclasts depending on testing. I wonder, at this point, if my doc will do CTX and P1NP or what my doc means by "monitoring"....maybe DEXA? I am getting a second opinon next week and will ask.

I was on Fosamax for some years then Reclast for 5 years. Was drug free for quite a few years until Dexa in 2021 showed severe osteoporosis. Started on Prolia. Between Jan 2022 and April 2023, I had 3 fractures due to osteoporosis each requiring surgery. Doctor said Prolia not effective and stated Tymlos last week. When I asked about treatment after Tymlos was told “will discuss later “. Did anyone take Tymlos prior to Evenity?

I hope you continue to have minimal side effects. I go tomorrow for my 5th set of injections. After my 4th set, I started to feel some other side effects that I am now not happy with. I will discuss this tomorrow when I see the MD. I also want him to order some blood work that I feel is needed based on the book " Good Bones" which I feel everyone should read.

I encourage you to read " Great Bones" by Dr McCormick, he goes into detail which lab work should be done prior to starting any medication. It is a great resource for anyone who has Osteoporosis.

I have no idea about the other drugs. I can only tell you that my Physician said Reclast and Bosphosphonate stay in your bones for a long time, that why I have the dental problems and dificulty having extractions and implants.

@kay44 how long were you on a bisphosphonate/Reclast and what dental problems?

Dentists are really afraid to do extractions, implants etc. but the serious issues, my doc said, are mainly with cancer patients on high doses and/or folks on them for a long time. Prolia and Reclast and other bisphosphonates are all anti-resorptives and I was told Evenity is too for the last half of treatment.

Having on infusion of Reclast after a bone-builder "locks in" gains and because it stays around for awhile, we might be able to take a break in meds. So that is a positive side to the long lasting effect of Reclast.

Right- I keep reading about the very long half life of Reclast- that it stays in your body virtually forever.
I read one explanation that as it’s deposited in your bones, the osteoclasts do their thing ( breaking down bone) thus releasing the Reclast.
So I’m wondering why we’re advised to take it every year for 3-5 years???

I also read another study that said a half dose, as well as every 18-24 months is as effective as usual administration.

* I’d post a link but the studies don’t allow it somehow. If interested I can try to post that.

@leslie2121 I have also read a half dose is just as effective. My doc is nervous about me and is giving me a 20% dose when I finish Tymlos next month. After 3 months I am supposed to call to tell him what dose I want next. Full dose is 5mg so he is giving me 1mg.