Hello, myfablife! I take 1 mg tacrolimus in the morning and 1/2 mg tacrolimus at night. No other immuno suppression medication. Note that Mayo allows me to have a low level because I have had zero episodes of rejection after the first year of transplant passed(yes, the first year is a roller coaster of adjusting medication dosage)and my liver panel numbers are stellar. The other element is how our bodies process the medication, some need more, some need less and we have no control over that. What matters is the level that comes up on your labs, not the number of pills you take. Best to you!