Hi @ske22!

I just came across this thread and so much of your post resonated with me. I'm 36, a former athlete who is in otherwise good health, but having been having similar AI symptoms the last 14 months (so still early in the "journey") and had my first rheum appointment in August after a positive ANA (1:640, atypical/speckled) in March and elevated CRP with every blood test since. Today I got a call that my Eos is also elevated and I'll be going back in to retest it in a few weeks' time. I have no diagnosis.

Negative for RF and anti-CCP. Getting crazy night sweats from time to time (we have to keep the room at 65 and have the ceiling fan on), and over the last 6 months increasingly severe menses with shortened time between cycles--had to be tested for premature perimenopause just to time it out. My care team is part of a large research and teaching hospital, but still no dice. I've seen a rheumatologist, endocrinologist, PCP, and will be getting a second opinion from a rheumatologist out of network next month.

I was struck by your description of the rash; I have a very similar issue! It started on my elbow and would slowly migrate towards my wrist, and then started to appear on the topside of my forearm. Tiny, itchy bumps that were either light red or skin colored. Worse in the heat/sweaty conditions. Left behind an oddly textured, scar-like spot where they clustered. Docs thought it was eczema, but it didn't respond to eczema drugs.

Currently on 400mg of plaquenil daily, which seems to be slowly helping the chronic swelling in my hands/feet, but still suffer from fatigue, exhaustion, and insomnia. If you get any updates, would love to know!