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Bispecific antibodies For Multiple Myeloma

Posted by lgeorge @lgeorge, May 26, 2023

Good Day,
Has anyone investigated or have been offered Bispecific antibodies to treat multiple myeloma or for any type of cancer? If so, have you heard or have you gotten good results with this treatment?

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Moderator
Colleen Young, Connect Director | @colleenyoung | Jun 5, 2023

@lgeorge, I had to look up this new treatment option for patients with myeloma that uses antibodies to activate the patient's own T-cells to kill their tumor cells.
- Bispecific Antibodies in Multiple Myeloma: Opportunities to Enhance Efficacy and Improve Safety https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046900

Is this treatment option available for you? Will you be part of a clinical trial?

REPLY
lgeorge | @lgeorge | Jun 5, 2023

Well not at the moment. I have been following it but i wasn't sure if anyone as of yet been offered this as a first line of treatment.

Thank you for the article

REPLY
scottp777 | @scottp777 | Mar 26 11:56am

Yes. I was treated with what was going to be called Pavarutamab, which in the study was called AMG-701. Amgen pulled the study because two other drugs were FDA approved before Amgen could get theirs out. I received it for one year. I was able to achieve MRD Negative for one month, which was great. I'm now at "small monoclonal protein detected, " and have been for almost two years. Side effects were not bad.

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1 reply
Moderator
Colleen Young, Connect Director | @colleenyoung | 1 day ago
In reply to @scottp777 "Yes. I was treated with what was going to be called Pavarutamab, which in the study..." + (show)
@scottp777

Yes. I was treated with what was going to be called Pavarutamab, which in the study was called AMG-701. Amgen pulled the study because two other drugs were FDA approved before Amgen could get theirs out. I received it for one year. I was able to achieve MRD Negative for one month, which was great. I'm now at "small monoclonal protein detected, " and have been for almost two years. Side effects were not bad.

Jump to this post

@scottp777, it sounds like the trial drug helped you. Should treatment be necessary in the future are you eligible for one of the other approved drugs?

REPLY
1 reply
scottp777 | @scottp777 | 1 day ago
In reply to @colleenyoung "@scottp777, it sounds like the trial drug helped you. Should treatment be necessary in the future..." + (show)
@colleenyoung

@scottp777, it sounds like the trial drug helped you. Should treatment be necessary in the future are you eligible for one of the other approved drugs?

Jump to this post

I am still eligible for Cart-T, and a host of other treatments. AMG701 was a bi-specific to BCMA/CD3, and since I responded well to it, there is an expectation that CART-T would work well also, should I need it in the future.

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