Reclast Infusions: Side-effects & Recovery time

Posted by cindydee @cindydee, Mar 20, 2018

I just had a reclast infusion last week and have had serious side effects. I had the worst flue like aching for 5 days then my lefty arm became full of inflammation in the wrist, elbow and shoulder which caused extreme pain and I lost the ability to straighten my elbow. Ultrasound showed huge amounts of fluid throughout the arm. The right arm is now starting to have the same symptoms. The pain is excruciating. Has anyone else experienced anything like this? Neither the ER doctor nor the Dr. who prescribed the procedure knew what to do to ease the symptoms. Both arms from fingertips to shoulder are swollen and neither elbow will straighten. Anyone else have adverse reactions to the reclast infusion? If yes, how long did it last?

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Taking medication for osteoporosis requires a risk/reward calculation. My primary care physician, who is not a medication pusher, suggested Evenity because my osteoporosis was pretty bad. I went through my 12 shots without side effects. I had my Reclast infusion on May 9th and reported flu like symptoms for a day and a half and thought that was the end of it. But on May 16th I started having major digestive problems and aches & pains in various bones and joints. My bone scan did reveal significant improvement so the Evenity was worth it. I won't have another infusion of Reclast. I already had one hip replaced because of arthritis and osteophytes. Now my other hip is giving me problems. If I have that one replaced, I won't need to worry about hip fractures! BTW, I am 73.

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I didn't go to the hospital but I was sure sick with pain. I had Reclast Feb. 28 and I am still have bouts of severe bone pain. They come and go. I will never have it again. The doctor told me after 3 infusions (that is 3 years) I would be good for 10 years. Well, I am 75 and I am not willing to give up 3 years of living for 10 years---by that time I will be 88! Gees!

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I am seeing a nephrologist this week to see if my kidneys can handle even a 20% dose of Reclast. Was in the ER last night and eGFR was low again at 37. I am seeking a second opinion on next steps scheduled for 6/30, infusion of Reclast is scheduled for 7/10, and I talk again to Dr. McCormick in between. I have started my last pen of Tymlos so that sets a time limit on my deliberations!

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@lizzabeth

I didn't go to the hospital but I was sure sick with pain. I had Reclast Feb. 28 and I am still have bouts of severe bone pain. They come and go. I will never have it again. The doctor told me after 3 infusions (that is 3 years) I would be good for 10 years. Well, I am 75 and I am not willing to give up 3 years of living for 10 years---by that time I will be 88! Gees!

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My bone pain is still painful and I had it 2 years ago

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@czs

A friend of mine had a Reclast infusion which sent her straight to the hospital. She said that the pain in her body was horrendous and felt like all of her bones were broken, especially in her back. She was never so frightened in her life. The symptoms improved and she was soon fine, but she said she would never take Reclast again. She was later told that if they give you an IV of fluids along with the Reclast, or you drink a lot of water, that the symptoms are less likely to happen. Something like that anyway.
I have significant osteoporosis, and Reclast is definitely off my list of possible medications.

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so awful to hear...I had a similar experience...scary drug; or so it appears.
Stay well and hope your friend recovers fully--

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I posted previously about having random joint, muscle, and bone pain starting after my Reclast infusion. Other people have mentioned a host of bad reactions and I am wondering how long they lasted. Thanks.

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Hello all—May 24, 2023 I have my first Reclast infusion. It was given over 45 minutes. I took Tylenol before treatment and drank several glasses of water.
I had a headache, and body ache for 2 days. After that, all is fine.
Was scared about the infusion—-but all is well.

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@windyshores

I am seeing a nephrologist this week to see if my kidneys can handle even a 20% dose of Reclast. Was in the ER last night and eGFR was low again at 37. I am seeking a second opinion on next steps scheduled for 6/30, infusion of Reclast is scheduled for 7/10, and I talk again to Dr. McCormick in between. I have started my last pen of Tymlos so that sets a time limit on my deliberations!

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I am so sorry you are going through this. Has anyone thought your kidney issues could be from tymlos? I knew someone years ago that had a similar problem with kidneys following forteo.
I hope all goes very well for you and you get to take the smaller dose of reclast and it does the job.
Best wishes.

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@trishw99

Hello all—May 24, 2023 I have my first Reclast infusion. It was given over 45 minutes. I took Tylenol before treatment and drank several glasses of water.
I had a headache, and body ache for 2 days. After that, all is fine.
Was scared about the infusion—-but all is well.

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Hello,
How soon after last Evenity injection (or other treatment) did you have Reclast infusion? Was it a full dose? You indicated 45 minutes…..was this 15 minutes of Reclast, with 15 minutes prior and after of something else? THANK YOU

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Had my first (& probably only!) Reclast last November. A couple days later woke up to greatly swollen knee ( just right one) where I couldn’t bend past 30°, or put weight on it as it was very painful. Felt fluid all around it. Living in a 3 story house was hard!
I laid on the couch & used cold packs on it. After a few days put a light compression wrap to help resolve the swelling.
Thankfully it returned to normal after a week and seems fine.
I felt crappy for a couple months- tired, achy, nausea- but feel mostly normal again.
My endocrinologist suggested Tymlos or even a 2nd round of Evenity in the future.
I don’t think I want anything for a good while.

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