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MDS and cognitive decline

Blood Cancers & Disorders | Last Active: 6 days ago | Replies (22)

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@loribmt

Hello @bdglass, @marco88, @kgerbitz and @dabls6
I did a little research online to see if there were any articles related to MDS and cognitive decline. There are several and I posted links to the two I felt were most informative.
https://pubmed.ncbi.nlm.nih.gov/15973668/
https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.22151
There is evidence of a relationship between the anemia associated with blood disorders and the lack of blood supply to the brain. When hemoglobin numbers are low the brain doesn’t receive the normal oxygen supply which can result in cognitive decline.
Have any of you required blood transfusions? Did you notice a change afterwards?

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Replies to "Hello @bdglass, @marco88, @kgerbitz and @dabls6 I did a little research online to see if there..."

I have not had transfusions. But I’m the last two weeks my count went from 7.9 to 9.2 and I feel much more like myself, mentally and physically.

My husband has just been diagnosed with MDS after having JAK2 for about ten years. His memory and cognitive skills have been in noticeable decline for about four yrs. This year, he became extremely anemic and his cognition seemed much worse. After a transfusion, he has improved in energy and cognition both. Unfortunately, his hemoglobin is starting to decline again and his oncologist is reviewing various cancer treatments. I also am not sure if the cognitive decline has been due to the cancer or the anemia and if treatment for MDS can help all symptoms. He is in denial about all his health issues, and it’s a real struggle to work with him on going to doctor visits. Anyone with similar experiences?