Pseudomonas: What antibiotic treatment worked for you?

Posted by Stella Tucson @fraytv, Apr 21, 2023

Has anyone been on Tobramycin for 3 months for treatment of pseudomonas? I would appreciate any comments good or bad & did it kill the pseudomonas. I was in the hospital twice for pneumonia. & pseudomonas. I was on Toby for 28 days with the understanding it would be 28 days on, 28 days off, then reevaluate. This was with my pulmonologist that has now left the practice. I started having hearing loss & my voice got very raspy while using Toby, & it tasted bad. I started seeing another pulmonologist at another practice that sent me to an Infectious Disease doctor on my first visit with him, the ID told me to stop the Toby & he put me on Meropenem antibiotic through picc line for 2 weeks. I feel the Meropenem did more good for me than the Toby. When I saw my new pulmonologist for the 2nd time he wants me to use Toby for 3 months continuously, no other options. I told him I would think about it because of the side effects of Toby, he was not happy with me. I have made an appt with ID dr to see if there are any other options. Would appreciate any feedback.

There was a person on this forum that asked me to post my experience with the Meropenem. I got the picc line as an outpatient at the hospital. A nurse from a compounding pharmacy came out the same day to administer my first dose & to make sure I didn’t have an allergic reaction & to teach my husband & I how to administer the med. It was for 14 days, given 3 times a day, every 8 hours. A nurse came out 3 times during treatment to change the dressing. I am allergic to numerous antibiotics so was glad it went well. I feel this antibiotic did more good for me than the other 3 antibiotics. Praying this antibiotic did the job, I have been sick for over 5 months. Thank you!

Interested in more discussions like this? Go to the MAC & Bronchiectasis Support Group.

@liz440

I am on that treatment. No side effects at all (hearing is fine no tintinitus). I was unable to take Tobi and was on Merem IV and now I'm on Sodium Chloride 3% plus the Azithro (250 mg) 3 times a week. (also Breo and Albuteral PRN) I have only been on this treatment since December but so far no downside. People on here say though that it can cause resistance (MAC etc.) but I guess that is a risk one has to decide to take. I haven't had a relapse but what means I don't know!

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Thank you for responding. Glad to hear you are not having any side effects. Wishing you the best.

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@fraytv

Has anyone been on azithromycin antibiotics 3 times a week for maintenance of pseudomonas & if so does it work & did you have any bad side effects? My pulmonologist wanted me to be on Tobramycin 3 months straight after I had already been using it for 28 days. I told him due to the side effects I preferred not to. After talking to the Infectious Disease dr he wants me to try the azithromycin antibiotic 3 times a week as maintenance for the pneumonia & pseudomonas I had late 2022 & again this year. I have bronchiectasis. Would appreciate any comments. Thank you!

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I take 3 a week. No better or worse. I do need to take a good probiotic or I have stomach cramps and some diarrhea.

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@mimmzy

I take 3 a week. No better or worse. I do need to take a good probiotic or I have stomach cramps and some diarrhea.

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Thank you for the feedback. Wishing you the best!

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I have recently had extensive sinus surgery and a pseudomonas infection was found. I have taken a lengthy round of cipro and am using medicated sinus rinses. Has anyone had any experience with this type of infection?

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@jeang45

I have recently had extensive sinus surgery and a pseudomonas infection was found. I have taken a lengthy round of cipro and am using medicated sinus rinses. Has anyone had any experience with this type of infection?

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No, I have never heard of that. I'm curious, have you had Covid? It seems (me personally) it attacks a lot of things in our bodies. I had sinus surgery in 1994 and later developed a 3 month sinus infection that wouldn't go away. The ENT swabbed my nose and I had 3 types of bacteria growing in my sinuses. He put me on Clindamycin - an antibiotic that wasn't used a lot and it cleared up. I also used prescribed nasal rinses (which was...back then....Neosporin rinse) and it worked great. It takes a while to heal up after sinus surgery. I am so glad I had it done as it has helped me to breathe better and to have less sinus infections. I am hopeful this will clear you up. Blessings & Hugs....

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@jeang45

I have recently had extensive sinus surgery and a pseudomonas infection was found. I have taken a lengthy round of cipro and am using medicated sinus rinses. Has anyone had any experience with this type of infection?

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Hi @jeang45, pseudomonas is a group of bacteria that can cause various types of infections. I moved your message about your recent diagnosis of pseduomonas to this existing discussion:
- Pseudomonas: What antibiotic treatment worked for you? https://connect.mayoclinic.org/discussion/pseudomonastobramycin-meropenem/

I did this so you can read previous posts and connect easily with members like @fraytv @irenea8 @pjas972j @leilam @fdixon63 @megan123 @liz440 @mimmzy and others.

You may also be interested in this related discussion:
- Should 4+ Pseudomonas be treated? https://connect.mayoclinic.org/discussion/should-4-pseudomonas-be-treated/

Jean, is the ciprofloxacin working for you? Was the infection limited to the nasal passages or also found in your lungs?

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@colleenyoung

Hi @jeang45, pseudomonas is a group of bacteria that can cause various types of infections. I moved your message about your recent diagnosis of pseduomonas to this existing discussion:
- Pseudomonas: What antibiotic treatment worked for you? https://connect.mayoclinic.org/discussion/pseudomonastobramycin-meropenem/

I did this so you can read previous posts and connect easily with members like @fraytv @irenea8 @pjas972j @leilam @fdixon63 @megan123 @liz440 @mimmzy and others.

You may also be interested in this related discussion:
- Should 4+ Pseudomonas be treated? https://connect.mayoclinic.org/discussion/should-4-pseudomonas-be-treated/

Jean, is the ciprofloxacin working for you? Was the infection limited to the nasal passages or also found in your lungs?

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I took 42 days of cipro, 500 mg, 2xday. I just finished it last week. I have also been on a prescription sinus rinse and will continue it for 2 more months. My doctor also found the infection in my upper back molar. Rather than have a root canal which gets rid of infection 95% of the time, I opted to have the tooth extracted which is a 100% rate. I did have Covid in July, 2022, but had had sinus problems before that. I am hoping the cipro has worked!

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