As promised, my successful tapering off Effexor (Venlafaxine)

Posted by sheffieldsmith @sheffieldsmith, May 31, 2020

Below you will find the tapering plan that I used to successfully wean myself off Effexor (Venlafaxine). Feel free to share this with your doctor If you would like. I researched and came up with this plan, which was approved by my doctor, although she thought I could probably have weaned myself off sooner. But the reality is that we all have differing tolerance levels for tapering and weaning off this powerful drug from our bodies. Some people can taper faster, but usually not those who have been on this drug for years (like myself, since October 2002). I tapered off EffexorXR 150mg capsules about 5 years ago down to 75mg, and was on that maintenance dosage for a couple of years until I started weaning off the 75mg a year ago in April 2019. As of October, 2029, I’ve been withdrawal symptom free, but I still have occasional periods of anxiety when triggered. But I realize these waves of anxiety will soon pass, and I cope by deep breathing, taking a walk, having a cup of chamomile tea, etc. Cutting my exposure to watching upsetting news has really helped a lot as well. These days I seek things that bring joy and peace in such a turbulent world. Wishing you all a successful weaning off this powerful drug.

Weaning off Venlafaxine XR 75mg (Effexor-(extended release)capsules:
Weaning plan off plan that worked for BSS:
1. Inform your doctor you are tapering down from 75 mg Venlafaxine and ask them to prescribe 37.50 tabs to help with tapering doses (1/2 dosage down from 75 mg Venlafaxine capsules). The tabs are easier to cut into halves and quarter dosages than counting out beads from the capsules.
2. Begin your taper only after you are on a non-withdrawal symptomatic dosage level. If you were having w/d symptoms at 75 mg, you’ll need to go back to the level at which you were symptomless and stay there for 2-3 weeks before deceasing to a slow taper. NOTE: after successfully tapering from 150mg Venlafaxine down to 75mg for a month, I was unable to tolerate a drop cold turkey from a daily dosage of 75mg down to 37.50mg (50%) without having bothersome withdrawal symptoms of dizziness, brain fog, brain zaps, and nausea. So after researching various tapering plans, I came up with a slower tapering schedule my body could tolerate to finish the tapering from 75mg to 37.50mg, and then on to complete the tapering. Your body may even need slower tapering, so adjust according.
3. Week 1-2: Take 75mg caps MWFSu; take 37.50mg tab on alternate days Tu,Th, Sa. At the end of week 2, if you only have relatively mild to no withdrawal symptoms, proceed to week 3. IMPORTANT: If you have intolerable symptoms, adjust to a slower tapering schedule by adding an additional 1/2 tab on the alternate days (or take a total of one and a half 37.50 tabs on alternate days). You’ll then have to tweak the rest of your tapering schedule. If all goes well, proceed with week 3.
4. Week 3-4: Cut a few 37.50 tabs in half with a pill cutter or exacto knife blade to create quarter pieces. Take 37.50mg tab on MWFSu and take 3/4 tab on alternate days Tu, Th, Sa.
5. Week 5-6: Take 3/4 of a tab MWFSu, and take 1/2 tab on alternate days Tu, Th, Sa. If only mild symptoms, proceed to week 5.
6. Week 7-8: Take 1/2 tab on MWFSu; and take 1/4 tab on alternate days Tu, Th, Sa. If no symptoms, continue to week 7.
7. Week 9-10: Take 1/4 tab on MWFSu; and take 1/8 tab (cut 1/4 tabs in half) on alternate days Tu, Th, Sa. *Notice the quartering of doses into crumbs now...very important to keep small dosage tapering to remain withdrawal symptom free.
8. Week 11-12: Take 1/8 tab crumb on MWFSu; take none on alternate days Tu, Th, Sa. *If skipping alternate days produces symptoms, stay on 1/8 tab crumbs for a couple of weeks before alternating skip days for a couple of weeks.
You’ll find that this schedule may have to be tweaked for you by extending the time you stay on a taper...possibly up to 3-4 weeks before beginning a new tapering down. It all depends on how you tolerate the first two weeks.

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Profile picture for mbryan @mbryan

Hi! Thanks for responding. I have heard that it is super hard to get off of, but not that hard. Wow. Makes sense - my symptoms have calmed down for the most part, but I constantly am hungry, or have this feeling in my upper abdomen, and if I don't eat in a certain amount of time, it gets worse and I feel super faint all of a sudden and get really clammy and then I just start to sob. I also have constant diarrhea. Sorry if that's TMI, but what were your symptoms like?

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That is not TMI! I have been on a lower dose of Effexor for 2 weeks now and I still have diarrhea, fatigue, panic, and extreme vertigo. I actually just tried to shower and almost passed out. Glad to hear that I’m not the only one who uncontrollably sobs for no apparent reason. Do your symptoms lessen after eating? I get very hungry but I can’t seem to eat and it makes me weak.

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Profile picture for mbryan @mbryan

I am having trouble staying full/feeling full/feeling constantly hungry. I need some advice on what to eat. Is this a serotonin problem that the medication causes as a withdrawal symptom? Has anyone else also gotten off of this medication?

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Thanks 🙏🏻 for all the insight. I feel the Mayo Clinic performs a wonderful service providing this forum for patient experiences.

Namaste 🙏🏻

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Profile picture for graciepeanut521 @graciepeanut521

That is not TMI! I have been on a lower dose of Effexor for 2 weeks now and I still have diarrhea, fatigue, panic, and extreme vertigo. I actually just tried to shower and almost passed out. Glad to hear that I’m not the only one who uncontrollably sobs for no apparent reason. Do your symptoms lessen after eating? I get very hungry but I can’t seem to eat and it makes me weak.

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Yes, I think I unctollably sobbed about 3 times yesterday, lol. I'm sorry to hear about that! That one symptom lessens after eating typically, yes. I take pantoprazaul to help with any acid reflux because sometimes that can upset your abdomen/stomach and it help for the most part. I haven't made it through a full day of work yet, though.

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Profile picture for mbryan @mbryan

I am having trouble staying full/feeling full/feeling constantly hungry. I need some advice on what to eat. Is this a serotonin problem that the medication causes as a withdrawal symptom? Has anyone else also gotten off of this medication?

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My doctor won’t prescribe Effexor or Paxil any longer due to the extreme tapering issues.

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Profile picture for graciepeanut521 @graciepeanut521

Hey there!
I’m also very slowly tapering off Venflaxine because when I tried to quit cold turkey I could not take the withdrawal symptoms. Fun fact: my doctor told me that Venflaxine is harder to withdraw from than heroin! I have only tapered down 20mg in the last two months, but I’m rooting for you! It’s interesting that you can’t seem to feel full. Are you having any other side effects?

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replying to @graciepeanut521 . I too am tapering off of this medication, and in all honesty, feel horrible. I am feeling more on edge than normal, irritated, angry(and I am not an angry person by nature) and very anxious, or rather more anxious than usual. As far as feeling "full" do you mean when you are eating? I do not have much of an appetite because of my liver/pancreas disease, so I am not having this symptom you described. I will see my neurologist tomorrow to discuss these symptoms among other things, and inquire if he can give me something other than what I have so that I can relax a bit more easily.
Good luck and hang in there. We can do this.

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Profile picture for sears @sears

My doctor won’t prescribe Effexor or Paxil any longer due to the extreme tapering issues.

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That makes a lot of sense! That's good that they are not prescribing it any more.

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Profile picture for frances007 @frances007

replying to @graciepeanut521 . I too am tapering off of this medication, and in all honesty, feel horrible. I am feeling more on edge than normal, irritated, angry(and I am not an angry person by nature) and very anxious, or rather more anxious than usual. As far as feeling "full" do you mean when you are eating? I do not have much of an appetite because of my liver/pancreas disease, so I am not having this symptom you described. I will see my neurologist tomorrow to discuss these symptoms among other things, and inquire if he can give me something other than what I have so that I can relax a bit more easily.
Good luck and hang in there. We can do this.

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The “feeling full” was in response to the original post. I myself do not have an appetite while withdrawing. It’s been about 3 weeks since I lowered my dose of Effexor and my appetite is slowly coming back, but for a while I could not eat at all.

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Profile picture for graciepeanut521 @graciepeanut521

The “feeling full” was in response to the original post. I myself do not have an appetite while withdrawing. It’s been about 3 weeks since I lowered my dose of Effexor and my appetite is slowly coming back, but for a while I could not eat at all.

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Oh, wow. That definitely makes sense to not have an appetite! I know it's different for everyone, but I swear this is the weirdest feeling that I'm experiencing. because it's not necessarily hunger all of the time, but a feeling in my upper abdomen that recently has gotten a little better. Usually it helps if I eat, but I'm not too sure if it fully helps.

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Thank you so much for posting this - I had been on Venlafaxine for many, many years - now I’ve tapered off successfully thanks to your advice.

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Profile picture for sears @sears

My doctor won’t prescribe Effexor or Paxil any longer due to the extreme tapering issues.

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I tapered off Effexor several years back. I had a horrible time and thought I was losing my mind. I went on celexa for a few years only to start cymbalta two years ago. Never felt well on any of them and now tapering off cymbalta. It’s not going well. I listened to a talk by a man who had an easier time coming cocaine than coming off antidepressants.

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