As promised, my successful tapering off Effexor (Venlafaxine)

Posted by sheffieldsmith @sheffieldsmith, May 31, 2020

Below you will find the tapering plan that I used to successfully wean myself off Effexor (Venlafaxine). Feel free to share this with your doctor If you would like. I researched and came up with this plan, which was approved by my doctor, although she thought I could probably have weaned myself off sooner. But the reality is that we all have differing tolerance levels for tapering and weaning off this powerful drug from our bodies. Some people can taper faster, but usually not those who have been on this drug for years (like myself, since October 2002). I tapered off EffexorXR 150mg capsules about 5 years ago down to 75mg, and was on that maintenance dosage for a couple of years until I started weaning off the 75mg a year ago in April 2019. As of October, 2029, I’ve been withdrawal symptom free, but I still have occasional periods of anxiety when triggered. But I realize these waves of anxiety will soon pass, and I cope by deep breathing, taking a walk, having a cup of chamomile tea, etc. Cutting my exposure to watching upsetting news has really helped a lot as well. These days I seek things that bring joy and peace in such a turbulent world. Wishing you all a successful weaning off this powerful drug.

Weaning off Venlafaxine XR 75mg (Effexor-(extended release)capsules:
Weaning plan off plan that worked for BSS:
1. Inform your doctor you are tapering down from 75 mg Venlafaxine and ask them to prescribe 37.50 tabs to help with tapering doses (1/2 dosage down from 75 mg Venlafaxine capsules). The tabs are easier to cut into halves and quarter dosages than counting out beads from the capsules.
2. Begin your taper only after you are on a non-withdrawal symptomatic dosage level. If you were having w/d symptoms at 75 mg, you’ll need to go back to the level at which you were symptomless and stay there for 2-3 weeks before deceasing to a slow taper. NOTE: after successfully tapering from 150mg Venlafaxine down to 75mg for a month, I was unable to tolerate a drop cold turkey from a daily dosage of 75mg down to 37.50mg (50%) without having bothersome withdrawal symptoms of dizziness, brain fog, brain zaps, and nausea. So after researching various tapering plans, I came up with a slower tapering schedule my body could tolerate to finish the tapering from 75mg to 37.50mg, and then on to complete the tapering. Your body may even need slower tapering, so adjust according.
3. Week 1-2: Take 75mg caps MWFSu; take 37.50mg tab on alternate days Tu,Th, Sa. At the end of week 2, if you only have relatively mild to no withdrawal symptoms, proceed to week 3. IMPORTANT: If you have intolerable symptoms, adjust to a slower tapering schedule by adding an additional 1/2 tab on the alternate days (or take a total of one and a half 37.50 tabs on alternate days). You’ll then have to tweak the rest of your tapering schedule. If all goes well, proceed with week 3.
4. Week 3-4: Cut a few 37.50 tabs in half with a pill cutter or exacto knife blade to create quarter pieces. Take 37.50mg tab on MWFSu and take 3/4 tab on alternate days Tu, Th, Sa.
5. Week 5-6: Take 3/4 of a tab MWFSu, and take 1/2 tab on alternate days Tu, Th, Sa. If only mild symptoms, proceed to week 5.
6. Week 7-8: Take 1/2 tab on MWFSu; and take 1/4 tab on alternate days Tu, Th, Sa. If no symptoms, continue to week 7.
7. Week 9-10: Take 1/4 tab on MWFSu; and take 1/8 tab (cut 1/4 tabs in half) on alternate days Tu, Th, Sa. *Notice the quartering of doses into crumbs now...very important to keep small dosage tapering to remain withdrawal symptom free.
8. Week 11-12: Take 1/8 tab crumb on MWFSu; take none on alternate days Tu, Th, Sa. *If skipping alternate days produces symptoms, stay on 1/8 tab crumbs for a couple of weeks before alternating skip days for a couple of weeks.
You’ll find that this schedule may have to be tweaked for you by extending the time you stay on a taper...possibly up to 3-4 weeks before beginning a new tapering down. It all depends on how you tolerate the first two weeks.

Interested in more discussions like this? Go to the Depression & Anxiety Support Group.

Had we all known we wouldn’t have. Eye pain. I haven’t heard that as a side effect but that doesn’t mean anything. Everyone’s different. I have extremely dry mouth, face sweats, low libido, and weight gain. (High blood pressure and cholesterol) I’m working out which helps…especially if you’re getting off of effexor. I do wish I never ever took this drug. I think my life could have turned out a lot different. I did try many times tho to stop. I am going to this time!

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Hi when u went of Effexor did u experience any serious withdrawal effects afterwards. i weaned myself down to 3.5 mg it went pretty smooth or at least the symptoms were tolerable, but then when i went off for good for 2 weeks i felt ok then things really turned for the worse for about 7 weeks now i feel terrible, just very depressed no appetite and no motivation, just wondering if there is light at the end of the tunnel? or if u felt this way? I'm switching to a nutrition route for trying to get over my original depression, all true out the tapering it was fine but now things are pretty rough for me...
Hope to hear Back Thanks.

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@joeh23

Hi when u went of Effexor did u experience any serious withdrawal effects afterwards. i weaned myself down to 3.5 mg it went pretty smooth or at least the symptoms were tolerable, but then when i went off for good for 2 weeks i felt ok then things really turned for the worse for about 7 weeks now i feel terrible, just very depressed no appetite and no motivation, just wondering if there is light at the end of the tunnel? or if u felt this way? I'm switching to a nutrition route for trying to get over my original depression, all true out the tapering it was fine but now things are pretty rough for me...
Hope to hear Back Thanks.

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Hi did u see my post?
Thanks...

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Thank you so much for posting this - I had been on Venlafaxine for many, many years - now I’ve tapered off successfully thanks to your advice.

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I’m 74yrs old and been on effexor 25+years. Because of cognitive issues, my doctor (neuro psychiatrist) has tapered me off Effexor by the 4th week. 3 days later I began to experience those awe full symptoms. I’m toughing it out Because for the 1st time in 25 years I woke up rested /connected with life. I don’t want to start taking them again. How long before the the worst of the symptoms nausea and nightmares ends?

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Thank you! This is really helpful!

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I am tapering from 150mg by reducing by 2.5 percent every 14 days. I cannot tolerate more than a 5% reduction per month. Please all be aware that cutting your effexor dose too quickly can make you ill and suicidal. you may not be able to safely operate a vehicle. My mom’s doctor just told her to reduce from 150mg to 75mg with no taper. this is horrific advice. many doctors do not understand withdrawal from these drugs and the drug manufacturers are not providing accurate or any discontinuation advice because they want to keep customers. Often times you may feel fine at first on a large reduction but the withdrawal often has a delayed effect. this taper schedule here is good but I also suggest anyone planning to get off effexor or other antidepressants go to survivingantidepressants.org make an account and get advice. they take harm reduction approve and suggest no more than a 10 percent reduction a month as severe withdrawal causes injury to your nervous system. Ive attached a photo of my taper schedule. the website i posted provides this calculator. I have my starting dose of 150 and a reduction of 2.5 percent every 14 days. I will be at 75 mg by february 2024. YES it takes long to safely ween from effexor, some might be able to handle 10 percent a month but more than that is not ideal

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@mryktn

I’m 74yrs old and been on effexor 25+years. Because of cognitive issues, my doctor (neuro psychiatrist) has tapered me off Effexor by the 4th week. 3 days later I began to experience those awe full symptoms. I’m toughing it out Because for the 1st time in 25 years I woke up rested /connected with life. I don’t want to start taking them again. How long before the the worst of the symptoms nausea and nightmares ends?

Jump to this post

you need a slower taper schedule please see my comment

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@joeh23

Hi when u went of Effexor did u experience any serious withdrawal effects afterwards. i weaned myself down to 3.5 mg it went pretty smooth or at least the symptoms were tolerable, but then when i went off for good for 2 weeks i felt ok then things really turned for the worse for about 7 weeks now i feel terrible, just very depressed no appetite and no motivation, just wondering if there is light at the end of the tunnel? or if u felt this way? I'm switching to a nutrition route for trying to get over my original depression, all true out the tapering it was fine but now things are pretty rough for me...
Hope to hear Back Thanks.

Jump to this post

this is really common for the withdrawl to be delayed. it is recommended to hold at the lowest dose for some time before going off completely. please go to survivingantidepressants.org and make an account . wonderful people who have weened themselves will give you great advice

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@frances007

Thank you @sheffieldsmith.
I have been on Effexor 150 mg for many years, and thought it was a great medication until I began experiencing terrible eye pain. Having never read about the side effects, I finally did and saw that eye pain was one of the more serious side effects. I contacted my doctor and he lowered my dose to 75 mg. After a day or so I began to feel quite sick, but attributed the feeling to my disease. Last night I finally went on line and read an interesting article in the Lancet, which describes Effexor as one of the more difficult antidepressants to taper off. I send a note to my doctor advising that I would not normally question his discretion, I thought that perhaps cutting my dose in half was too much and that I wanted to discuss a tapering schedule when I see him this coming Monday.
I read your post with great interest, as is very helpful information. I had no idea the ramifications of taking this medication, although it worked for me until it did not. In fact, I would read posts by other people on this platform who complained about Effexor, and I would think to myself, " I wonder what the problem is, as I have no problem." Obviously the drug is not the right choice for me, and in all honesty I am trying to get off of many of my medications in an effort to avoid further damage to my liver.
Thank you

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doctors are continually telling their patients to make huge reductions on effexor with no taper and it is not appropriate. it can make you suicidal and basically unable to function. you should taper by no more than 10 percent a month. so 10 percent reduction would out you at 135 mg for rhe first month. please go to survivingantidepressants.org people there have fantastic advice and provide tapering calculators

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