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Modified Folfirinox chemotheraphy regimen. Is it still effective?

Posted by kathy2000 @kathy2000, Mar 31, 2023

Hello. My husband was diagnosed in December with Stage 4 Pancreatic Adenocarcinoma Cancer. Irregular appearance of the pancreatic tail with area of hypodensity measuring 3.5 x 2.2 cm and numerous hepatic metastic lesions in liver. No other known areas of concern. The folfirinox regimen was started on December 12th. After 5 rounds every other week we hit a rough patch and became hospitalized (9 days) for severe dehydration / malnutrition / very low blood counts which stemmed from a combination of the chemo and uncontrolled diarrhea. After a 3 week break, we resumed chemo eliminating the leucovorin, reducing the irinotecan dose to 120/m2 and omitting the boost of the 5-FU bolus. We have now had 2 more rounds every other week of this regimen.

Has anyone had such a shift and is this still a viable treatment? We will meet again on Monday and will ask these questions but looking for someone in a similar situation.

Thank you.

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ratnam | @ratnam | Mar 31, 2023

Hi ….my mother aged 65 has been diagnosed with stage 4 pdac in Feb 23….she is being given sequential gem/nab for three weeks, followed by mFolfox once in a six weeks cycle…Do you know of anyone else on a similar regime?

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ratnam | @ratnam | Mar 31, 2023

This kind of a change is quite common from what I’ve read….any element thought to be causing toxicity is either reduced in dosage or cut out altogether….efficacy will be known in someone’s case only after a while.

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kathy2000 | @kathy2000 | Mar 31, 2023
In reply to @ratnam "This kind of a change is quite common from what I’ve read….any element thought to be..." + (show)
@ratnam

This kind of a change is quite common from what I’ve read….any element thought to be causing toxicity is either reduced in dosage or cut out altogether….efficacy will be known in someone’s case only after a while.

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The wait is always the issue. The next CT is several weeks away. I wonder if they ever add back the dosage? We seem to be on solid ground again. Always more questions than answers.
🙂

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kathy2000 | @kathy2000 | Mar 31, 2023
In reply to @ratnam "Hi ….my mother aged 65 has been diagnosed with stage 4 pdac in Feb 23….she is..." + (show)
@ratnam

Hi ….my mother aged 65 has been diagnosed with stage 4 pdac in Feb 23….she is being given sequential gem/nab for three weeks, followed by mFolfox once in a six weeks cycle…Do you know of anyone else on a similar regime?

Jump to this post

I'm sorry I don't but maybe someone on here does. I've read about some intuitions using a type of disruptive therapy approach, so the cancer becomes confused and is less able to adapt to one type of treatment. I'm just a caregiver so not qualified to say if that is the situation you have. Good luck though!

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