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Mirtazapine for insomnia -- concerns

Sleep Health | Last Active: Apr 5, 2023 | Replies (6)

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@ripley

Has your Dr mentioned trying Trazodone before Mirtazapine? I've been taking Trazodone for sleep for over a year. I started at 50mg and now take 100mg. It's an anti-depressant with a side effect of sleepiness. I was waking up frequently during the night, so tried switching to 7.5 mg of Mirtazapine but only took it one night. It helped me sleep through the night but I felt groggy and tired for the next 3 days so stayed with Trazodone. Trazodone has a half life of 5-13 hrs, while Mirtazapine's half-life is 20-40 hrs. My routine now is taking 2.5mg Melatonin before bed, which helps me fall asleep. I wake up 1-2 hrs later and then take 100mg Trazodone which helps me sleep a few more hours. A helpful website with user reviews on both drugs (and other sleep meds) is Drugs.com. Google the name of the med you want to research and add "for sleep reviews" after it and the website should come up.

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Replies to "Has your Dr mentioned trying Trazodone before Mirtazapine? I've been taking Trazodone for sleep for over..."

I had a sudden unset of insomnia 3 weeks ago -- could not fall asleep. My dr had addl reasons to recommend Mirtazapine, I have been uncomfortable given my research (half-life is one reason, they say 16hrs) but he pushed it and I am not in a position to refuse (complicated).

I have taken 7.5mg at bedtime for the last three nights. While I do fall asleep, I wake up more than once and every sleep episode comes with a dream. It's not healthy sleep. I felt sleepy only the day after the 1st pill.

The advantage I see is that at the low doze it's not anti-depressive. I only looked superficially @Trazadone and it did not attract me, don't recall why. What side-effects did u experience?

If there is no improvement I may try Trazodone -- starting with 25mg.