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Aquagenic Pruritus

Skin Health | Last Active: Aug 21, 2023 | Replies (56)

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@davef

Long time poster on this thread; and for the last 60 days, I have been ITCH-FREE!!! Even without taking Beta Alanine (BA).
Unfortunately, I've done three things that might have affected the outcome and from my personal feelings of least effective to most effective, they are:
1. I severely cut back on alcohol. Mentioning it only because it was happening at the same time. I really dont think this was a cause of loosing the itch and after this weekend of concerts and entertaining, still don't believe it to be a primary cause.

2. I treated the Actin Keratosis AKs on my arms and legs with a combination of Trenointin & Florouracil at the same time. The trenointin really roughs up the skin on arms and legs to allow the florouracil to penetrate and work as needed. **(I will caution you to not treat your upper and lower arms at the same time and always put on a sun sleeve or bandage below the elbow to keep the skin from sticking to itself while you are sleeping. )

3. What I think did the most good.
I started on 10mg / day dose of Paroxetine.
Paroxetine is a anti depressant but at this dose not strong enough to notice any changes in behavior or thinking. I noticed the reduction in the Aquagenic Puritius itching after 4-5 days and after 10 days, I could take a hot shower, then towel dry immediately afterward; something I haven't done in years. Also used a hot tub for the first time in years.

So I continue to travel with BA on me at all times, but haven't needed it since starting on the Paroxetine. I have stopped treating the AKs, and will update this post in 2 weeks, once the arms and legs have fully healed.

The list of Meds I have tried to date:
Paroxetine - Jury is in deliberation on this one but I think this is it
Beta Alanine - Proven to work, you need to take it 20 minutes prior to needing it
Gabapentin - didn't work for me, and the brain fog was something horrible
Dupixent -didn't work for me but I was on it for only 6 months and apparently it can take 12 months
? some salt based med, that gave me a headache worse than the Korean Soju hangover I had in 1994

Best of luck to everyone
I'll update in 2 weeks

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Replies to "Long time poster on this thread; and for the last 60 days, I have been ITCH-FREE!!!..."

Good news! Please keep us updated on your progress…
Question…did your doctor prescribe the Paroxetine specifically for AP or itch? Or was this a lucky side effect?
My doctor is “by the book” and wants to see evidence, especially medical papers demonstrating evidence…is there anything out there on Paroxetine and itch?
I’ve been popping Beta Alanine a few time a day for over 5 years…I also have change in temperature itch flares…it works but I would like to find a better solution…