@faithshouse
My experience with Mirtazapine: I experienced suddenly weight gain after using Mirtazapine. It was prescribed to me (15 mgs) because I had a really hard time sleeping at night, and it helped. ( I still take it today but at a very low dosage.) (The problem is, and was, that my entire life I have been slender (if not skinny) and now I find it difficult to deal with all these extra pounds. :<(

As far as I know, Mirtazapine is an antidepressant that also helps if you cannot sleep at night. (Since your husband was not used to it, Mirtazapine made him sleep all the time. But maybe if he had not cut it off right away, he might have noticed some improvements.

Mirtazapine is also given (my PD explained to me), to cancer patients who have lost weight, and appetite, because Mirtazapine makes you very hungry all the time (or at last, this is what I experienced with Mirtazapine/Remeron).