Thrush after anti-rejection treatments: What helps?

@jbaggi 😊
Yes, I agree with you. I have heard that with some people (as rare occurrences), vaccines can stimulate the immune system in a way that can cause mild rejection. I am so surprised that after six years, you are experiencing this now. Maybe there is something related to the vaccine and the way your system experienced it. I had four unsuccessful vaccines, then Evusheld, then got sick with covid and needed an infusion of monoclonal antibodies. That was my covid experience.
Regarding ALLOSURE, my test results started at .18, then went to .20, then .23 and I am due for another test in January. My scores have slowly crept upwards, which is not a good thing. What have your ALLOSURE results look like?

I had my first ALLOSURE test several years after my transplant. My second one was in May. I had another one last month. My personal opinion is that they should be done on a regular basis. Maybe we would have caught my rejection a little quicker. Not sure though.
Doc didn’t say anything about what may be causing the inflammation, but I’m sure they’ll let me know my next appointment.
I probably shouldn’t say this but I had absolutely no problems with my transplant until I started getting the Covid vaccines. In fact I didn’t have Covid for two years but got it two days after my 4th vaccine.
My Doc assures me the risk of rejection after getting the vaccine are rare, but it does happen.
Thanks for checking in.

Do you have an update to share? What worked for the thrush?

@silvergirl36, I have just now seen your question about Thrush treatment and want to say that had 2 cases of oral thrush since transplant and was prescribed the medication, Nystatin Swish and Swallow.

Interesting for me is that I went to the ER when I began to feel like I was swallowing broken glass while deciding to call doctor in a few days. But as can happen, that was not the best choice! Why do these things always get worse after hours when the doctors offices is closed? This occurred after a hiking trip and airplane flight and began as a dry scratchy throat that I credited to dry mountain air, exertion and breathing on uphill trails, and the dry airplane air. I later learned that those 3 things, plus the need for extra use of my albuterol inhaler for exercise induced asthma, had set me up for a 'perfect storm' kind of scenario for thrush. I had never had it before. The ER gave me a 5 day prescription and tole me to see my PCP at the end of 5 days. My PCP added another 5 days so I used it for 10 days.
One time after that, when I began to feel like something was going on, I contacted my PCP and we caught it early. The Nystatin again worked for me.

Silvergirl36, I read that you are a caregiver. Is this the kind of information that you were looking for?

Hi @jbaggi 😊
I hope all is well with you! I know you said you are taking another ALLOSURE and DSA test in late February to monitor your inflammation. You also mentioned that you have had ALLOSURE tests in the past. My test result numbers are climbing, but not high enough to warrant a biopsy yet. In the past, what kind of Allosure and DSA blood results did you get? I am getting concerned about my numbers. I have lowered immune suppression meds to fight my BK virus (for the last 5 months).

Hey:
Don’t know what my numbers were, but they were fairly high. I tried checking mychart for results but they weren’t listed. I’m repeating both tests on Feb 6th so I’ll let you know what they are.
I know what issues you can have with rejection drug doses and infections. I’ve had breathing issues for the past two months that won’t go away no matter how much prednisone or antibiotics they give me. I have an appointment with a pulmonologist the same day I’m at the transplant clinic. Hopefully they can figure it out.
I hope you get your issues resolved soon. I know it can be discouraging at times , but hang in there. Docs can usually get it figured out.

Hey:
Don’t know what my numbers were, but they were fairly high. I tried checking mychart for results but they weren’t listed. I’m repeating both tests on Feb 6th so I’ll let you know what they are.
I know what issues you can have with rejection drug doses and infections. I’ve had breathing issues for the past two months that won’t go away no matter how much prednisone or antibiotics they give me. I have an appointment with a pulmonologist the same day I’m at the transplant clinic. Hopefully they can figure it out.
I hope you get your issues resolved soon. I know it can be discouraging at times , but hang in there. Docs can usually get it figured out.

@jbaggi, I like your realistic and positive vibes! Yes it can be discouraging at times, and we do have to trust our doctors, the experts. I have complete trust and confidence in my Mayo transplant teams and my PCP, who have guided me in the right direction for 13 years post transplant. It sounds to me as if you are under the care of a very competent and caring team, too. I hope that in 13 years you will be announcing the same thing.

@jbaggi, @hello1234 - Here is a support group where members are talking about ALLOSURE tests as well as other tests for rejection. I know that you will enjoy meeting and sharing with other about the tests.
-Transplants: blood test to test for rejection
https://connect.mayoclinic.org/discussion/transplants-blood-test-to-test-for-rejection/
jbaggi, I will be thinking of you as you have your appointment with the pulmonologist. I hope that you learn something about your breathing issues.
I experienced breathing issues several years after transplant, and we think my issue was related to lowering and getting off prednisone (as indicated by research and combination of liver and kidney transplant).