Hi!

Meant heartfelt thank yous post!

Question: Have you or anyone else who has > 600 EBV Nuclear Ag Antibody IgG results been tested or diagnosed w/ a primary autoimmune disease?

Last month I asked my internist to order a serum EBV Nuclear Ag Antibody IgG (U/mL) test, along w/ other EBV tests. The sole out of range result was EBV Nuclear Ag Antibody IgG (U/mL) test > 600.

I googled + discovered the following info in a research article (link below), which I’m thinking may be of interest.

- high anti-EBNA-1 antibody levels may reflect a deficient control of the EBV infection, increasing the tendency toward autoimmunity
- the risk of MS increased with increasing anti-EBNA-1 antibody levels (p for trend <0.0001)
- elevations in anti-EBNA-1 antibody levels become increased between 15 and 20 years before the first symptoms of MS and thereafter remain constant over time

Interestingly, over a few decades, I received the following diagnoses
- 1974 (age 17) Infectious Mononucleosis … which I only recently learned is EBV + a herpes virus.
- 1987 (age 29) Pars Planitis, now called intermediate uveitis, a condition I was advised is often seen with primary autoimmune diseases. Autoimmune disease test results were negative and pars planitis improved.
- 2011 (age 54) Hashimoto’s Thyroiditis
- 2021 (age 63) Relapsing Remitting Multiple Sclerosis. My early symptoms: 1) sudden leg weakness that lasted a few days then improved 2) bi-lateral tingling in my toes that over a few weeks rose to my waist then over weeks returned to my toes/feet/lower legs. Over 3 yrs, I consulted 3 neurologists, had multiple spinal MRIs that revealed a stable T7 lesion, numerous blood tests + several EMGs … was advised my tingling might be early peripheral neuropathy. On a hot day, I experienced significant difficulty walking. A brain MRI revealed lesions + spinal tap revealed oligoclonal bands resulting in an MS diagnosis … w/ a strong suspicion that I’ve had MS since the 1987 pars planitis diagnosis.

I’m most interested to learn
- if you or others w/ elevated EBV Nuclear Ag Antibody IgG results have received autoimmune diagnoses

Thank you again!

Article
“High Levels of Epstein–Barr Virus Nuclear Antigen-1-Specific Antibodies and Infectious Mononucleosis Act Both Independently and Synergistically to Increase Multiple Sclerosis Risk”

http://www.frontiersin.org/articles/10.3389/fneur.2019.01368/full