@blbird33, I am 13 years post transplant. I received a simultaneous liver and kidney transplant in April 2009 at Mayo Rochester. So, I have been taking tacrolimus as one of my immunosuppressant meds for 13+ years.
I used to tremble a lot, especially my hands. This made handwriting impossible for the first 2 - 3 hours after my morning dose. Over time, my medication doses reached a stable dosage and my labs are extended to every 3 months. My tacrolimus has been at a stable dose for, I'm guessing 7 years. My trembles do come back on occasion, bit it is something that I have learned to live with. It is a minor issue, considering the benefits of a healthy liver and kidney!

@mdplastics, I also had to make adjustments when driving. I need a quiet car with no radio or only one passenger, usually my husband. When traveling in an unfamiliar town with traffic, my husband is the driver! It is a plan that works well for us.