Hi @davef and welcome to Mayo Clinic Connect. I'm tagging @gardeningjunkie and @walisky who have had experience with DUPIXENT® (dupilumab), albeit not for aquagenic pruritus.

Dave, how long have you been dealing aquagenic pruritus?

My husband does not have aquagenic pruritus but he has been taking Dupixent. A dermatologist recommended it for my husband's itching and his breathing problems. It cleared up his skin and he no longer struggles to breathe. A nurse came to the house to show him how to inject himself every other week. It's very simple. A specialty pharmacy delivers it to our house. It has to be stored cold and then allowed to warm to room temperature for 45 minutes before injecting. The used needle goes into a provided Sharps container which has a prepaid postage box to use when full. I looked up the condition you have and I hope that this is the answer to what sounds like a difficult to live with problem.