Hey all! I've suffered with AP since I was about 13 (currently 27) and in the last 6 year it has increasingly gotten more severe and more frequent. I have tried EVERYTING! Diet changes, lotions, creams, oils, change in body wash, razors, shaving cream, etc. Finally started seeing a doctor for it because I am going crazy! I've called my mom after a shower many times in the last few years in full on tears and explaining how crazy I feel! So far my doctor has tried me on individual and combinations of meds including Zyrtec, Cyproheptadine, Amitriptyline, and Gabapentin. Now about to start naltrexone with the Xolair shots as the next option if the naltrexone fails. I am happy to have finally found a doctor that listened to me and is working with me every step of the way. She is literally running down the list of medications that follow separate physiological pathways that can result in severe itching. My doctor also linked my cold uticaria to my AP; apparently most AP sufferers have an allergic reaction when their body heats up; but mine does it when it gets to cold too fast. Unfortunately my AP is triggered by humidity as well and I live in Florida where it rains and is super humid constantly. And moving to a cooler dry climate is supposed to help but my allergy to the cold restricts me from doing so..

I have seen that some people get relief from beta-alanine supplementation. I know beta-alanine is most commonly found in pre-workouts and I can't recall ever having relief from itching while I was taking pre-workout. Recent heart issues prevent me from taking pre-workout any longer. So I am thinking of trying the beta alanine on its own if the naltrexone doesn't work; prior to starting the Xolair shots (which have me a little nervous). I was just curious if anyone had any evidence based text about beta alanine in the treatment of AP; the healthcare professional in me is curious how it works physiologically/pathologically to stop the itch..

And I am so sorry that everyone here suffers from AP; I would never wish this condition on anyone!