Has anyone tried anti-depressant medication for neuropathic pain?

Posted by greenacres @greenacres, Nov 13, 2021

I'm wondering how many people in this community with neuropathic pain have been prescribed some form of an anti-depressant along with or without Gabapentin to help ease the pain and if anyone has found this protocol helpful?

Interested in more discussions like this? Go to the Neuropathy Support Group.

willows | @willows | Apr 20, 2022

In reply to @greenacres "Hello @mcd123, @melody12, @willows, @rivermaya34 Thank you so much for responding and sharing. @willows Did you..." + (show)

In response to your question regarding an adjustment period I would say that no, I had been on amitriptyline for awhile and when the Pregabalin was added everything was fine right away.

fibromyalgia001 | @fibromyalgia001 | Sep 3, 2022

In reply to @debbie2021 "No I have not. To be honest I have never heard of it," + (show)

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bonniethompson1234 | @bonniethompson1234 | Sep 5, 2022

Hi, yes, I am taking 30 mgs of duloxitine (Cymbalta) along with my first dose of gabapentin 100 mg. I take a second gabapentin about an hour before bedtime. It helps so much it surprised me. My dentist told me about it. Sorry if I answered this before.

Chris Trout, Volunteer Mentor | @artscaping | Sep 5, 2022

In reply to @virginiashort "I am taking Gabapenten and Duloxetine and am doing ok" + (show)

Me too......I am taking 120 mg of Duloxetine (Cymbalta) in the morning and 600 mg of Gabapentin at bedtime. It is working for me, especially with the addition of a dropper of a medical cannabis 2:1 (CBD/THC right before I turn ff the light. Makes for a very nice sleep. If there isn't a perfect solution, then I will stick with this one.

@virginiashort and others. Thanks for being part of this conversation.
Chris

alfer | @alfer | Nov 26, 2022

Looking for experience with tricyclic antidepession drugs to treat PN? Particularly Nortriptyline.

John, Volunteer Mentor | @johnbishop | Nov 26, 2022

In reply to @alfer "Looking for experience with tricyclic antidepession drugs to treat PN? Particularly Nortriptyline." + (show)

Hello @alfer, You will notice that we moved your post to an existing discussion on the same topic here so that you could meet members like @melody12, @artscaping and others who have discussed Nortriptyline for treating neuropathy.

-- Has anyone tried anti-depressant medication for neuropathic pain?:
https://connect.mayoclinic.org/discussion/anti-depressant-medication-for-neuropathic-pain/
Has your doctor suggested trying Nortriptyline to see if it helps with your PN?

Chris Trout, Volunteer Mentor | @artscaping | Nov 26, 2022

In reply to @johnbishop "Hello @alfer, You will notice that we moved your post to an existing discussion on the..." + (show)

Greetings @alfer. As @johnbishop mentioned, nortryptyline was the first medication my neurologist prescribed in hope that I would be able to sleep at night. Pain and fear were keeping me awake. It was very helpful and I continued taking it for a couple of years until I found how helpful medical cannabis could also be. To this day, my nighttime medication is a 2:1 CBD/THC tincture. My original dosage has been increased as the SFN (small fiber neuropathy) symptoms increased.

The mornings were a problem for me also. As the pain ranked up in the morning I was quite frustrated by noon. So.....we tried Duloxetine for anxiety and I still take it to this day, having increased the dosage from 30 mg to 120 mg. It helps the pain by controlling the anxiety.

Good luck with your medication decisions. Just don't make any changes without discussing them first with your doctor.

What else are you using to control the effects of neuropathy?

May you be free of suffering and the causes of suffering.
Chris

alfer | @alfer | Nov 27, 2022

In reply to @artscaping "Greetings @alfer. As @johnbishop mentioned, nortryptyline was the first medication my neurologist prescribed in hope that..." + (show)

Thanks for all your experiences. I am not on any meds yet have only doing natural remedies such as multivitamins with ALA and essential oils. They seem to help but find the PN is getting stronger in my feet. I also not sure what kind of doctor to go to. A Neurologist or or a pain management spine doctor ? Any suggestions?