Hi @njtodctode, The tapering game with PMR can be the pits especially if you try to taper too fast. Sorry to hear you are struggling with managing the symptoms. In another discussion where we connected you mentioned you were going to try again at 20 mg to see how you felt. Did you already go back to 20 mg and then taper down again?

I'm wondering if the following discussion might be helpful to read through a few of the posts and see if you can make a connection that helps.
--- PMR Dosages and Managing Symptoms: https://connect.mayoclinic.org/discussion/pmr-dosages/

I've never tried MSM but others may have some experience. I did find this information that might provide some insight:

-- 8 Science-Backed Benefits of MSM Supplements:
https://www.healthline.com/nutrition/msm-supplements