Hi @darren12, welcome. As you likely already know, endometrial stromal sarcoma tumors start in the supporting connective tissue (stroma) of the lining of the uterus (the endometrium). We here in this group can certainly help to support you and share experiences to help you support your wife. This must've come as a shock to both you and your wife.

If you are looking for a second opinion, I highly recommend the Mayo Clinic for complex, rare cancers. You can self-refer on behalf of your wife or request that her currently physician submit the referral. You will find all the information to get started here: http://mayocl.in/1mtmR63

Darren, has it been determined if her ESS is low-grade or high-grade? How is she doing? How are YOU?

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