Tips on minimizing withdrawal symptoms from Effexor (aka Venlafaxine)

Posted by richyrich @richyrich, Nov 2, 2016

I have been taking Effexor/Venlafaxine for years and tried to get off it a few times but each time I try to give up the chemical withdrawal symptoms are a horror story and I give up giving up. Anyone got any tips or tried and tested strategies? Thank you

Interested in more discussions like this? Go to the Depression & Anxiety Support Group.

@tmgg
Just taper extremely slowly.
If you have any withdrawal symptoms increase your dose and restart your taper even slower.
You might want to consider a new doctor.
Best of luck,
Jake

REPLY
Profile picture for Leonard @jakedduck1

@tmgg
Just taper extremely slowly.
If you have any withdrawal symptoms increase your dose and restart your taper even slower.
You might want to consider a new doctor.
Best of luck,
Jake

Jump to this post

Thank you yes I will do so.
T

REPLY

Have you guys tried adding cbd with no Thc?

REPLY
Profile picture for pitilina @pitilina

Have you guys tried adding cbd with no Thc?

Jump to this post

@pitilina Yes I have at night which seems to help me sleep while tapering off Lorazepam slowly.

REPLY

Hello fellow sufferers.
I feel like this drug, ( with similar chemical properties to pcp) is poison to my system.
I've been researching how to get off this drug-venlafexine. Here's what I found:

1. Some people can taper faster than others.
2. It is a good idea to start with a 10% taper and hold for a few weeks. Sometimes as long as 4
3. The next lower dose than 37.5 ER is 25mg IR. Which is taken 2-3x a day. And can be cut smaller.
4. 25mg IR is water soluble and this makes it easier to taper to the lowest possible dose.
5. Symptoms should be minimal or gone before next taper.
6. If a reduction gives you intolerable symptoms, reinstate and hold that dose for a few weeks before next taper. This means it was too much of a taper.
7. Some people take a year or longer to completely taper off this drug and that's ok.
8. Listen to what your body is telling you.
I was on 37.5er for a few years. It stopped working and was giving me terrible side effects. I wound up in the ER June 2022. I stopped cold turkey for a month and initially felt a little better. July I tried Prozac which made me terribly sick vomiting and diarrhea. Then I tried Pristiq which worked for about a week then made me extremely angry and aggressive and feeling very agitated. Beginning August I started 25 mg immediate release. Half a tablet three times a day. It did help but unfortunately with all I had done to my nervous system I was taking it sporadically. I had 3 days of no medication then I made a liquid out of my 25 mg IR tablet however what you should know is this enters the bloodstream very quickly. It made me quite sick at 6.25ml 2x a day. I tried one day to switch back to 1/4tab and immediately vomited.
So as of right now I am taking 1 ml of liquid mixture two times a day. This is a very small amount but it is staving off my withdrawal symptoms for now.

REPLY

Hi,
I am currently tampering off of Effexor. I am in the beginning of month 3 of this process. Each month, I reduce the amount by 37.5mg. At the start of each reduction, I have gotten diarrhea & short lasting abdominal queasiness. Last month the queasiness occurred over a longer time period than the actual diarrhea. I have been using Metamucil as a supplement and eating yogurt on a daily basis. When I feel queasy I also eat Saltine style crackers. I have been trying to use exercise (powerlifting 3 days a week & cardio at least 2 days a week) as a natural means to replace the serotonin. The first month I was aware that I was more irritable than normal & was teary on several occasions. This past reduction, I noticed I became teary & was engaged in ruminating thoughts. That observation allowed me to change my behavior which ended the tears. I am also more sensitive than normal to heat. Although I no longer feel depressed, I am continuing to see my therapist on a weekly basis through out this process. This is the second time I have tappered my amount of Effexor. The first time was a disaster. My then-psychiatrist recommended too big of a jump. I quickly ended up back on the prior dosage. This time my goal is getting off of it completely.

I would love suggestions as to what else I can try for the gastro issues.

REPLY
Profile picture for deeschmee @deeschmee

Hello fellow sufferers.
I feel like this drug, ( with similar chemical properties to pcp) is poison to my system.
I've been researching how to get off this drug-venlafexine. Here's what I found:

1. Some people can taper faster than others.
2. It is a good idea to start with a 10% taper and hold for a few weeks. Sometimes as long as 4
3. The next lower dose than 37.5 ER is 25mg IR. Which is taken 2-3x a day. And can be cut smaller.
4. 25mg IR is water soluble and this makes it easier to taper to the lowest possible dose.
5. Symptoms should be minimal or gone before next taper.
6. If a reduction gives you intolerable symptoms, reinstate and hold that dose for a few weeks before next taper. This means it was too much of a taper.
7. Some people take a year or longer to completely taper off this drug and that's ok.
8. Listen to what your body is telling you.
I was on 37.5er for a few years. It stopped working and was giving me terrible side effects. I wound up in the ER June 2022. I stopped cold turkey for a month and initially felt a little better. July I tried Prozac which made me terribly sick vomiting and diarrhea. Then I tried Pristiq which worked for about a week then made me extremely angry and aggressive and feeling very agitated. Beginning August I started 25 mg immediate release. Half a tablet three times a day. It did help but unfortunately with all I had done to my nervous system I was taking it sporadically. I had 3 days of no medication then I made a liquid out of my 25 mg IR tablet however what you should know is this enters the bloodstream very quickly. It made me quite sick at 6.25ml 2x a day. I tried one day to switch back to 1/4tab and immediately vomited.
So as of right now I am taking 1 ml of liquid mixture two times a day. This is a very small amount but it is staving off my withdrawal symptoms for now.

Jump to this post

This is a incredibly helpful list for recommended tapering, it’s paralleled what I’ve experienced, as well as my plan for eventually getting off this drug someday. Thank you

REPLY
Profile picture for kermit2021 @kermit2021

This is a incredibly helpful list for recommended tapering, it’s paralleled what I’ve experienced, as well as my plan for eventually getting off this drug someday. Thank you

Jump to this post

You are very welcome. Another great resource is Surviving Antdepressants. It's a wonderfully informative site 😊

REPLY
Profile picture for gaile12 @gaile12

Hi,
I am currently tampering off of Effexor. I am in the beginning of month 3 of this process. Each month, I reduce the amount by 37.5mg. At the start of each reduction, I have gotten diarrhea & short lasting abdominal queasiness. Last month the queasiness occurred over a longer time period than the actual diarrhea. I have been using Metamucil as a supplement and eating yogurt on a daily basis. When I feel queasy I also eat Saltine style crackers. I have been trying to use exercise (powerlifting 3 days a week & cardio at least 2 days a week) as a natural means to replace the serotonin. The first month I was aware that I was more irritable than normal & was teary on several occasions. This past reduction, I noticed I became teary & was engaged in ruminating thoughts. That observation allowed me to change my behavior which ended the tears. I am also more sensitive than normal to heat. Although I no longer feel depressed, I am continuing to see my therapist on a weekly basis through out this process. This is the second time I have tappered my amount of Effexor. The first time was a disaster. My then-psychiatrist recommended too big of a jump. I quickly ended up back on the prior dosage. This time my goal is getting off of it completely.

I would love suggestions as to what else I can try for the gastro issues.

Jump to this post

Hello. I am so sorry to hear that you are suffering. I, too, am trying to come of Effexor XR 75mg after 22 years. I was prescribed the drug for fibromyalgia which resolved years ago, but dr kept prescribing and I kept taking it. What a fool I was.

I have read a lot about weaning from Effexor because we simply cannot stop or reduce in big jumps or the side effects are awful. I have been getting advice from the Surviving Antidepressants website which is very helpful. If you sign up there, the moderators (who are very knowledgeable) will help you. There is also lots of info you can read. I have only been able to drop to 73 mg from 75 in 3 months and I have had some side effects, but if I have questions about how to handle it, I can get answers on Surviving Antidepressants. Please check them out. You will be glad you did. Take care and best wishes.

REPLY

It is so shameful that those who prescribe and sell these meds are not the ones who can help us discontinue these meds. That people actually have to take to the internet and join groups for help because the doctors and pharmaceutical companies have no clue. I’ll just never get over this. I took to the internet for help with benzo withdrawal. It gets more appalling every day and still nothing from the medical community.

REPLY
Please sign in or register to post a reply.