Hi Jackie,
I also added your question to the Sleep Health group (https://connect.mayoclinic.org/group/sleep-health/) so that other Bipap users can join the discussion.

Medications in the US are regulated by the Food and Drug Administration (FDA) to ensure they are safe and effective. The FDA's oversight includes American medicines or their active ingredients that are manufactured in other countries. These production facilities are regulated and inspected by the FDA. They are traced throughout production and distribution so you can be sure the medicine you get from your pharmacist have a reasonable assurance of safety and effectiveness. FDA ensures labels on medications direct patients on when and how it can be used and things to watch out for.

Foreign manufacturing facilities may or may not have the same oversight and regulation of their medications or products.

Regarding Sanyrene, I spoke with a Mayo Clinic phamacist and she verified that Sanyrene contains hyperoxygenated fatty acids and perfume. She also advises:

- "It should not be applied to broken skin. I have not seen high quality evidence that hyperoxygenated fatty acids in general or Sanyrene in particular further reduce the risk of pressure ulcers.

Skin that is overly warm, moist or overly dry such that there may be scaling or cracking increase risk so it’s important to maintain dry and moderate temperature airflow. Regular skin assessment and care are also important aspects of prevention.

A barrier liner made of cotton or moleskin that can reduce moisture and help keep skin dry may improve skin condition. Sometimes irritation is caused by headgear which is too tight. You want just enough tension to create a seal. You could also try a mask made of different materials. Any nasal lubricant used to reduce skin irritation with Bipap and should be petroleum-free to maintain mask integrity."

@jackieinsg Has your skin improved sinceusing the Sanyrene? Have you tried barrier liners?

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