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FDA approves polyneuropathy treatment for adults
The FDA has approved Amvuttra, an RNA interference therapeutic for the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.

Amvuttra (vutrisiran, Alnylam Pharmaceuticals) is administered through subcutaneous injection once every 3 months, the company said in a press release. The FDA approval was based on positive results from a global, randomized phase 3 study, which assessed the safety and efficacy of vutrisiran in participants with hereditary transthyretin-mediated (hATTR) amyloidosis with polyneuropathy.

Source: Adobe Stock.
Source: Adobe Stock.
“Twenty years ago, Alnylam was founded with the bold vision for RNA interference to make a meaningful impact on the lives of people around the world in need of new approaches to address serious diseases with significant unmet medical needs, such as hATTR amyloidosis,” Alnylam CEO Yvonne Greenstreet, MBChB, said in the release. “Today, vutrisiran has the potential to change the standard of care for people living with the polyneuropathy of this devastating disease.”

According to the release, 164 patients with hATTR amyloidosis were randomized 3:1 to receive 25 mg of vutrisiran by subcutaneous injection once every 3 months (n = 122) or 0.3 mg/kg of patisiran via IV infusion once every 3 weeks for 18 months (n = 42). The vutrisiran group was also compared with a placebo group (n = 77).

Among 114 participants who received vutrisiran, there was a 2.2-point mean decrease, or improvement, in the modified Neuropathy Impairment Score +7 after 9 months of treatment, compared with a 14.8-point mean increase reported in the placebo group. In addition, 50% of patients who received vutrisiran experienced improvement in neuropathy impairment compared with baseline.

All safety and tolerability endpoints were met after 9 months of treatment with vutrisiran. The most reported adverse events were arthralgia (11%), dyspnea (7%) and a vitamin A decrease (7%).

“We are so thankful to the patients, families and investigators involved in making Amvuttra a reality for the hATTR amyloidosis community,” Greenstreet said.

I’m 87 years old and have tingling and loss of feeling in my fingers. Does anyone have experience with this condition. I would like to hear any experience with this.

Welcome @councilman, I'm 79 and share your experience. I have small fiber peripheral neuropathy. I shared my story in another discussion here – Member Neuropathy Journey Stories: What's Yours? – https://connect.mayoclinic.org/comment/310341/.

Have you been diagnosed with neuropathy?

Hi Coleen, My name is Mary Munro. I am 74 years of age. I live in the Pacific Northwest. My neuropathy stems from a motor vehicle accident in 2017. I have nerve damage in all areas of my spine, but so far, neuropathy only in my legs.
I tried various materials, thread count, weaves of materials on which I could rest or cover my legs and not feeling like I was taking what was already akin to being ablaze, and adding a bed of nettles . Nothing worked. Bedding hurt. Clothes hurt. I asked my medical team if people went mad with this. There was no respite in sight. Then one day, I saw possible salvation in a fur coat I had hanging in my closet. I tried it. The fur felt glorious against my skin. It soothed rather than irritated. I could pull the sides of the coat up over my legs if they were chilled. The fur did not feel like I just dropped an anvil on my legs. This was heaven.
Then I started thinking about the many other suffers of neuropathy. How could I get them the same relief? Not everyone just happens to own a fur. What if this is a fluke and doesn’t work for anyone else but me? I have seen the use of mouton for bedridden patients so as to avoid bedsores. My idea has some already proven merit.
The thing with using my coat is that there isn’t the right kind of structure to continue without harming the pelts of fox. There are furriers that will convert a coat into a blanket or stole, but the cost is around $1,000. The cost of a fur blanket is around the same . The fur is then attached to a batting that provides a sturdy enough structure to the many pelts that make up the piece. With a coat, there is just a lining.

I have a mink coat that I will donate to someone who would like to try this to see if they get the relief I did. Then perhaps I could go about getting furs donated and funds to convert to blankets. “Furs for Nerves”. If you have a candidate or if someone from the forum wants to volunteer, I can ship it out. They can try it for a while, see if they get relief. Then perhaps a start on getting donated furs to individuals.
I am not making any sense.

I’m 87 years old and have tingling and loss of feeling in my fingers. Does anyone have experience with this condition. I would like to hear any experience with this.

Yes. My fingertips are numb. I was told it is due to carpal tunnel. It makes my hands very clumsy. I knock things down or spill because I don’t know where they are. Does that make sense to you?