Elevated amylase and lipase but pancreas appears normal. Thoughts?

Posted by thefam2016 @thefam2016, Oct 27, 2019

So this tuesday 10/22/19 i took my mom to have routine blood work done and they had order a amylase and lipase which amylase came back at 114 and lipase came back at 76, went for a ct with contrast on friday came back with a large hital hernia and that the pancreas appears normal. Mom has bad increase in generilized fatigue weight loss nausea vomiting night swaets and her brother recently passed away from pancratic cancer i am afaird to just let the pancreas appearing normal to just go like that i am concerned thay it might just be on the beginning stages of something underlining going on. What should i do from here does any one have recommendation in testing i should request to have done. Please any one that can give me some advice i would be greatful
Sincerely a very concerned daughter

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The normal lipase level for an adult over 60 years of age is 24-151. That coupled with a normal appearing scan might indicate that exploring other options for the cause of her symptoms might be in order. I would definitely seek a second opinion. Hope you find out soon!

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Profile picture for chrioli @chrioli

I’ve been having elevated lipase in the 3-400 range had a normal appearing pancreas on MRCP, normal liver with simple cysts, never drink or take medications. On endoscopy they found chronic gastritis and h pylori infection. I thought my lipase would go back to normal after h pylori treatment but it was 444 just last week. Any comments?

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@chrioli, has your lipase returned to normal since you last posted? When did you finish treatment for H. Pylori?

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I finished h pylori eradication about 3 weeks ago. My lipase was rechecked 1 1/2 weeks ago and was still elevated at 414

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Also I continue to not feel well with nausea, weakness/fatigue and weight loss though I’m eating a bland diet every 4 hours. Also lots of gurgling and belching still

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Profile picture for chrioli @chrioli

Also I continue to not feel well with nausea, weakness/fatigue and weight loss though I’m eating a bland diet every 4 hours. Also lots of gurgling and belching still

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Hi, I'm in a similar boat with gastritis, h.pylori and elevated lipase and amylase. I haven't been through treatment yet for h.pylori. I was wondering if you had any more information to share about your progress?

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Profile picture for Amanda Burnett @amandaa

Hello @roseb39 and welcome to Mayo Clinic Connect. As you will see, I moved your post to a discussion that is ongoing about having high lipase and amylase with normal pancreas. The benefit of doing so means that you have a chance to connect with all the members in this discussion that are having similar issues. I'd like to invite @thefam2016 @arnold1957 @astaingegerdm @harper7745 and @tigreyes2004 back to the conversation to greet you. Rose, would you mind sharing how high your lipase and amylase are?

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I have similar issues. I have high lipase and analyze, but they said my pancreas and liver look good on an MRI and CT scan. I take crayon with every meal and snack so I’m not sure what else could be wrong. Any suggestions or thoughts on this? of course I’m always worried about cancer somewhere. Thank you so much.

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Profile picture for judypville @judypville

I have similar issues. I have high lipase and analyze, but they said my pancreas and liver look good on an MRI and CT scan. I take crayon with every meal and snack so I’m not sure what else could be wrong. Any suggestions or thoughts on this? of course I’m always worried about cancer somewhere. Thank you so much.

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@judypville - good to hear that while you have high lipase and amylase with a normal pancreas, your pancreas and liver look good on a scan.

Are you noticing any particular symptoms?

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Not since I started taking Creon. I also changed my diet to low fat, really low sugar and low carbs. I just wondering why I still have high blood tests?

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Profile picture for judypville @judypville

Not since I started taking Creon. I also changed my diet to low fat, really low sugar and low carbs. I just wondering why I still have high blood tests?

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Hi, @judypville - great to hear about your symptoms. Your diet sounds super healthful.

When you say high blood tests, what substance are you meaning in your blood (e.g., glucose, cholesterol, hematocrit)?

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Profile picture for Lisa Lucier, Moderator @lisalucier

Hi, @judypville - great to hear about your symptoms. Your diet sounds super healthful.

When you say high blood tests, what substance are you meaning in your blood (e.g., glucose, cholesterol, hematocrit)?

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Lipase & amylase blood tests were still high.

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