Side effects of Pristiq

I have been on Pristiq for about 6 months. Prior I had lost approximately 50 pounds, I was told Pristiq was the cleanest among anti-depressants and would have no impact on my weight. I gained 25 lbs. Experiencing swelling in my throat, abdomen, causing a pressure under my diaphragm. I could no longer run, because I could not breathe.

After gaining the weight and NO MATTER the good diet choices or exercises (Cardio/Weights) the weight and swelling would not go away! My doctor checked my thyroid..All is well...it took me right back to the Pristq. Although my moods balanced out, the good began to taper and I lost interests in hobbies around me. The bad side effects, that were not suppose to happen, did.

I decided to take myself off. My physician asked what I thought would work, I said possibly Wellbutrin. I stopped taking Pristiq 3 days ago, I am taking 1 tab of Wellbutrin 150 mg a day for 3 days, and then I am to take 1 tab 150 mg 2x a day, after my first three days with no Pristiq.

I am very DIZZY, nauseated, can barely move without feeling like I am on a roller coaster. Hot flashes...I am hoping this will go away soon. Any comments??? How long the dizzy head will remain? If coming off of Pristiq is this debilitating ...it is not as clean as I was made to believe. It is VERY potent and I would not recommend it!

I will never take Pristiq EVER!

So glad to have found this forum. I have been on Pristique since Oct 2012. I started it b/c of perimenopause and several life stressors piling up, culminating when my father passed away. My family has a history of depression and I hated thinking I had it as well. Pristique certainly got me through - felt just numb enough to carry on and I could just drop off to sleep again and not be waking up at 4 o’clock in the morning. And I enjoyed eating, which isn't always a good thing. I still have little motivation outside of work and difficulty maintaing exercise, but I do it about 3 times a week.
I was taking 50 mg and so are several friends around the same age....with great effects they claim.
I have decided to come off of this for several reasons. I have gained weight and don’t feel good about myself physically and at 50 I need to be more physically conscious, I also have no libido left – but I’m cheeryish? My Mother has been on antidepressants for almost 40 years and has never been able to function without them (which is fine for her, she’s never questioned coming off them). My concern is that at 71, she has had elevated cholesterol, IBS, and arteriosclerosis. The sad part is that she is very active, biking, walking, works out 4x a week and teaches yoga and she eats like a saint. She has not been in a long term relationship for 25 years (I don’t think she misses that part 🙂 BUT I have to wonder if all her physical issues are not directly related to the 40 years of antidepressant use.
I do take depression seriously as my profession is in psychiatric nursing, but I have to wonder about the effectiveness of long term use of antidepressants? There is new work now with neurotherapy showing that altering brain wave function can have very positive effects on the three types of depression. I am trying this myself and even with only four treatments I am noticing differences in my mood, clarity and depressive tendencies.
Some research is now showing that these medications are not effective long term and may even cause rebound depressive symptoms. And that using pharmacological interventions is most effective for people that suffer from the most extreme major depressive disorder. The scary facts are that most research is funded and driven by the pharmaceutical industries so how are we getting the best information when that is the case?
My withdrawal from Pristique has been similar to others here, the dizziness, brain zaps, and a rushes of sensitivity with my feelings. It’s been about 7 days now and I quit cold turkey as I wasn’t on for that long and I was only taking 50mg. I have felt angry and really sad but honestly I hadn’t cried more than twice since October being on Pristique – and I was in some really sad places? I’m not sure that was a positive effect. I’ve cried 3 times this week – I think because of coming off Pristique and my brain readjusting. Life is sad and hard a lot of the time and I hope to have the fortitude and personal relational support to make it through – and maybe with some other methods of treatment like neurotherapy, yoga, breathing and other self-regulating techniques my brain can heal from whatever it’s set up was to begin with. I believe we can change our brains, but not just with cognitive techniques because the symptoms we deal with are in the limbic system and that needs help in gentler, physical ways. For me the jury is still out on pharmaceuticals, I am very skeptical about them for sure where women’s health is concerned.
Heres a couple of resoruces FYI:
CBC Ideas – Rethinking Depression parts 1, 2, 3
Swingle and Associates (Vancouver BC) – have a good website on neurotherapy

Thanks for posting all you brave people and I’ll let you know how long all this annoying zapping goes on for…hugs Sorry this is so long...
EJean

Taking 50mg Pristiq for 9 months and began an alternating day taper in February.
Every 14 days I add one more day without a pill. I'm now alternating 3 days off, 1 day on. Taking it each morning. No cutting.

Symptoms are only noticeable on the first decrease/add-on of one day in the taper cycle. Some 'brain zaps/electric feeling in the brain'. Mostly when changing focus or sudden eye movement. Not fun, but interesting. The goal is to expand to 4 days off, 1 day on until the end of May, then discontinue altogether and observe.

This website has been very informative. I told myself that I would not read anyone's horror story b/c in turn I will think about the aftermath too much and decide not to wean off of it. I was on 50 mg Zoloft and Xanax for a couple of months due to having two panic attacks (anxiety) about 4 months apart and I felt like a zombie on them. I went from about two months of 50 mgs of Pristiq to 100 mg Pristiq and Klonopin (as needed). Basically been on a med to treat anxiety since February of '13. I almost wonder if the Klonopin is more addictive than the Pristiq, but I'm in such a fog that it's hard to tell. I have always resorted to homeopathic remedies, but read that you cannot take St. John's Wort w/Pristiq as it is almost considered brain poisoning b/c it gives your system too much of a brain boost. I am considering weaning from Pristiq and relying on the Klonopin during the difficult moments. The Pristiq causes such fatigue and I have shallow breathing with it, making it hard to catch my breath or deep breathe. I am involved in yoga and truly enjoy it. Considering accupuncture but not sure if being on the medication while on it will be beneficial. Does anyone know or have any simple advice? Does anyone out there prefer to go the homeopathic route instead that has had any success weaning from this? God bless you all, and know you are not alone. Lean on the Lord as times like this may be His way of saying to depend on Him and His goodness and healing ability. He made us and knows us better than we know ourselves! I appreciate any recommendations....

I was on pristiq for a year, and 5 days ago my psychiatrist finally took me off of it! i only took 25 mg for a year (with klonopin as an emergency backup in case of sudden anxiety) and throughout the year i learned how to handle situations that i never thought i could handle on my own. i also noticed that i relied on klonopin less and less until i basically never took it anymore.
now that i am allowed to be off, i am so thankful that i was put on it, but realized that i am okay without it now! my mood began depending on myself, and didnt depend on the pill. this was also when i was making a scary transition into college (i am only 18 years old) and i am so glad i could do it.
the only problem i am having now is the withdrawal. my body is strongly affected by changes and i was wondering how long do you estimate it will last?
the first day i felt HORRIBLE. nauseous like i was going to vomit at least 5 times in one day. horrible stomach aches, constipation. it's day 5 now and i'm feeling slightly better, the only thing is i feel so so dizzy and really don't have motivation to do anything. i feel somewhat agitated, (not as bad as i did on day 1) my mood currently feels fine (no extreme happiness or sadness) the withdrawal is just very hard for me because i am an active runner and exerciser and i dont want to gain weight or feel sick during a workout.
the symptoms are becoming less harsh, but i still feel very hot, or very cold, somewhat nauseous, and very dizzy, kind of hazy like my head is in the clouds (unfocused)
please reply! its helpful to know someone went through or is going through the same thing i am! thank you!!
p.s. right now i am only taking the 25 mg every other day for a week. doctors orders.

Woo Hoo!! I am finally off Pristiq!!!! I am feeling normal again, the brain zaps have finally subsided to the rare side now (they are caused by your neurotransmitters firing) and I am just downright happy again! I am smiling, laughing and feeling like myself that I was beginning to question if she would ever be back again. All I can say to all of you is it will take time. There will be side effects while your brain is adjusting, and that is why is important to taper. I went from 100mg to 50mg and tapered off for 3 weeks. I had hoped to do it in 2 weeks but too many symptoms. I am hopeful in renewing my life. I never ever thought that this medication would actually start destroying my life. I lost all de sire to be part of life, felt empty and so emotionless. After 3 years I feel myself again. I am smiling again, joined a gym to help get rid of my weight gain. And just working out has made a difference. I really wish the best to all of you and know that it is a struggle. I did it and it was hard but I will NEVER go on a antidepressant again.

Taking 50mg Pristiq for 9 months and began an alternating day taper in February.
Every 14 days I add one more day without a pill. I'm now alternating 3 days off, 1 day on. Taking it each morning. No cutting.

Symptoms are only noticeable on the first decrease/add-on of one day in the taper cycle. Some 'brain zaps/electric feeling in the brain'. Mostly when changing focus or sudden eye movement. Not fun, but interesting. The goal is to expand to 4 days off, 1 day on until the end of May, then discontinue altogether and observe.

Taking 50mg Pristiq for 9 months and began an alternating day taper in February.
Every 14 days I add one more day without a pill. I'm now alternating 3 days off, 1 day on. Taking it each morning. No cutting.

Symptoms are only noticeable on the first decrease/add-on of one day in the taper cycle. Some 'brain zaps/electric feeling in the brain'. Mostly when changing focus or sudden eye movement. Not fun, but interesting. The goal is to expand to 4 days off, 1 day on until the end of May, then discontinue altogether and observe.