Side effects of Pristiq

Posted by Native Floridian @nativefloridian, Jan 7, 2012

Has anyone successfully tapered off Pristiq? If so, what was your plan? I am considering going off this medicine. I take 50 mg per day and have done so for about 2 years. I understand there are very significant withdrawal symptoms and I would like to stop taking Pristiq because it causes my heart to race when the time release happens. I am afraid this medicine may not be good for the heart because the clinical trials state that anyone with a heart condition was not allowed to take it.

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@frenchie

I was on the 50 mg Pristiq, and I discussed tapering off with my doc. (It's important to note that I only use minimum dosages of antidepressants for maintenance, and haven't suffered a major depressive episode for at least 20 years. It's quite possible that I don't need the meds anymore.) Doc recommended against cutting the pills in half, but encouraged me to try taking it on alternate days. He said if I noticed any depressive symptoms, resume daily use. I started tapering off in mid-December, and I'm now taking it every third day. I'll probably go to once every four days and then stop entirely. I've had no ill effects.

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you where right on point..had to take another pill of cymbalta..i am stuck don't know what to do next.....thanks for your inseight about this stuff

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Good news. I have read about every post on this forum and have yet to see a success story. Well, I am one. Quit cold turkey and the only withdrawal was one headache and two days of feeling a little "fuzzy". I feel so much better and happier off of this drug. Good luck to those of you trying to quit. May you have the success I had.

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I have been on Pristiq since August, 2012 for anxiety issues following thyroidectomy. I've been tapering off with 1/2 tab daily for 3 weeks. I haven't had a pill for two days and I feel fine this evening. I am hoping I can sleep ok tonight with no strange dreams (that's what happens when I miss a dose, usually.) Besides some initial fuzzy -headedness during the first 3 days, I feel great. Pristiq has been a great medicine, but I feel like I don't really need it. I would use it fulltime again if I ever had to, but for now I want to be free of it because, as many of you have mentioned, it took away the intensity level of my feelings...I was just neutrally happy and neutrally sad about things...One thing I did like about it is that I could cry once in awhile! Another reason I want to eliminate it is money. I can afford the meds, but I'd rather buy a cute top or jewelery each month!!! We gotta be pretty, girls! I will get on over this and keep saying my prayers to get me through middle age and old age dilemmas. God bless all of you. Take care of yourselves and enjoy life, now!

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@frenchie

I was on the 50 mg Pristiq, and I discussed tapering off with my doc. (It's important to note that I only use minimum dosages of antidepressants for maintenance, and haven't suffered a major depressive episode for at least 20 years. It's quite possible that I don't need the meds anymore.) Doc recommended against cutting the pills in half, but encouraged me to try taking it on alternate days. He said if I noticed any depressive symptoms, resume daily use. I started tapering off in mid-December, and I'm now taking it every third day. I'll probably go to once every four days and then stop entirely. I've had no ill effects.

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Keep trying, I know everyone on here is having various issues about coming off there drug. Some may be trying to come off to soon, but others like myself have been on this drug for a long time. 7 yrs for myself. I just know it was time. I felt better stronger and know it was time to come off. I tried three times. I have been scared. I am on my fifth day. I am feeling better every day. just don't give up if this is what you want. We are here for you!

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Well I had been on the medication for 2 years. Finally I asked my doctor after loosing my insurance if I could wean off of it. Of course every doctor practices differently and we should have took a longer period of time to come off of it, however he advised me to take one every other day for ten days. And then I could be done with it. I thought wow easier than I thought. Boy was I wrong. First I started having issues with my face being numb, especially my lips. My blood pressure would be crazy numbers either too high or too low, then the second week I had some numbness still but and it end of the week I began to feel my moods changing. I had a lot of anger and loss of words. I also should add as soon as I began coming off of the medication I began having a loss of short term memory. Now the third week being off of it, I no longer have facial numbness but do have extreme mood swings. Especially depression. They started off being mood swings all day everyday and now they come and go with severeness through the day. I feel awful. No one deserves to deal with the moods I've been having. All I know is I hope it doesn't last long and I don't have to go back to it or anything else. I also want to add I have been experiencing some mild uncomfortable chest pains. It was 50 mg and not a time release

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I quit pristiq abt. a month ago, cold turkey. I know!! Bad idea! I had forgotten my pill for 2 days & couldn't figure out why my head was having brain zaps. Then it dawned on me.So, I just didn't take anymore. Yes it was hell! Words didn't come out the was I intended, couldn't remember, & did I mention the brain zaps? (haha) That was the worst feeling. I've lost weight ,thats good. Nothing tastes right. It kind of changed everything. But I'm feeling more "normal". I Have feelings I had shoved to the side. Pristiq made me have no feelings at all, I couldn't cry, didn't have the same interests that I used to have. I talk more & seem to be getting better. I do take a zanax when I get anxious. I have never been diag. with depression that has a name! I would tell my Dr. I feel kind of blue. Oh your Depressed! So Im going to a Dr other than my primary doc, & get diag.(dont know how to spell that word) but you know what I mean. Heck by now, 35yrs later, I may not have depression. At that time in my life I was probably unhappy! I can't remember the name of the first script but theres been one after the other. Now the couch & TV is not my best friend!! I hardly ever sit down anymore, I'm up & staying busy. By taking pristiq for 3-4yrs. it seems like I went thru' life in a fog. My head is clearing, but the "brain zaps" are still with me, less & less tho'.

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@sassidede

I quit pristiq abt. a month ago, cold turkey. I know!! Bad idea! I had forgotten my pill for 2 days & couldn't figure out why my head was having brain zaps. Then it dawned on me.So, I just didn't take anymore. Yes it was hell! Words didn't come out the was I intended, couldn't remember, & did I mention the brain zaps? (haha) That was the worst feeling. I've lost weight ,thats good. Nothing tastes right. It kind of changed everything. But I'm feeling more "normal". I Have feelings I had shoved to the side. Pristiq made me have no feelings at all, I couldn't cry, didn't have the same interests that I used to have. I talk more & seem to be getting better. I do take a zanax when I get anxious. I have never been diag. with depression that has a name! I would tell my Dr. I feel kind of blue. Oh your Depressed! So Im going to a Dr other than my primary doc, & get diag.(dont know how to spell that word) but you know what I mean. Heck by now, 35yrs later, I may not have depression. At that time in my life I was probably unhappy! I can't remember the name of the first script but theres been one after the other. Now the couch & TV is not my best friend!! I hardly ever sit down anymore, I'm up & staying busy. By taking pristiq for 3-4yrs. it seems like I went thru' life in a fog. My head is clearing, but the "brain zaps" are still with me, less & less tho'.

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I have quit Pristiq a few times. This time I have decided to stop it entirely and permanently. I noticed that while on the drug I spend more time sleeping and have hot flashes when it is time to take the drug. My biggest issue with the drug is that I believe it is designed to be a drug that you can't get off of easily or if ever at all. My second biggest issue is that I am not depressed at all but really don't feel like doing anything anymore and that does not seem normal to me. I could just stay home forever. Even when suffering from depression, I didn't feel this way. I don't feel interested in much anymore and I don't socialize anymore nor have a desire to do the things that need to be done. I just feel as though I am a different person on this drug. I have always been a highly motivated person so it is noticed by everyone, especially my family. I would like to know if anyone else has had this experience on Pristiq? Third, my cholesterol is extremely high on this drug. I have taken it for 2 years now 50mg a day and the process of being satisfied without motivation has been a slow one and it didn't happen suddenly. Today is day 3 and my symptoms are hot flashes and perspiration and light headedness ~ difficulty concentrating and I am tired. Other than that I am fine. I am worried that I could become depressed again but the more I read about most prescription drugs, the side affects are bad so I want to try to see if I still need an antidepressant. Thanks for reading and sharing your stories.

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After 2 years on Pristiq the side effects became more than just a nuisance. My doc suggested switching to Cymbalta, after tapering off Pristiq. I started reducing my dose by 1/2 -- 1 50mg tab every other day. After 2 weeks, the worse symptoms are nausea, increased pain (Pristiq really works for nerve pain) and a general feeling of 'mental discomfort' -- being 'on edge'.

Prior to Pristiq, I was on Lexapro; my doc switched to Pristiq because I complained of side effects. However, the side effects of Pristiq are definitely worse, and I think Lexapro did a better job controlling my depression.

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Hello,
I have been on Pristiq since March 2011. Prior to that I was on Lexapro for about 5 years (for mild depression following my divorce). At first the Pristiq seemed to help (maybe the first month or two) - but then i started having trouble with concentration, memory (foggy thinking), and poor sleep. My doctor at the time then added xanax for sleep and adderall for concentration. Two years later and my health (physical and mental) has significantly declined... side effects now include blurred vision, weight gain (30lbs), short term memory loss, and worsening depression...sometimes have trouble sometimes getting through my day. Last October I resigned from my job - and thought I would take a few months to focus on getting my health back. I have stopped taking xanax (now take a natural supplement to sleep), exercise 2-3 times a week, and try to overall eat better. Nothing has really helped so I have come to the realization that I need to get off of Pristiq. Missed one day and the discontinuation symptoms were terrible - extreme dizziness, headache, body aches, brain zaps and "jumbled thoughts" - took me 3 days to recover which is not easy to do with three teenage boys.
Have been doing research trying to find information on how to get off Pristiq. It seems that a lot of people have been struggling on this drug - and not too many "success stories" on how to taper off... any advice/feedback from anyone who has found a way to successful get off - and stay off Pristiq would be MUCH appreciated!!
Thanks in advance,

Karen

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@sassidede

I quit pristiq abt. a month ago, cold turkey. I know!! Bad idea! I had forgotten my pill for 2 days & couldn't figure out why my head was having brain zaps. Then it dawned on me.So, I just didn't take anymore. Yes it was hell! Words didn't come out the was I intended, couldn't remember, & did I mention the brain zaps? (haha) That was the worst feeling. I've lost weight ,thats good. Nothing tastes right. It kind of changed everything. But I'm feeling more "normal". I Have feelings I had shoved to the side. Pristiq made me have no feelings at all, I couldn't cry, didn't have the same interests that I used to have. I talk more & seem to be getting better. I do take a zanax when I get anxious. I have never been diag. with depression that has a name! I would tell my Dr. I feel kind of blue. Oh your Depressed! So Im going to a Dr other than my primary doc, & get diag.(dont know how to spell that word) but you know what I mean. Heck by now, 35yrs later, I may not have depression. At that time in my life I was probably unhappy! I can't remember the name of the first script but theres been one after the other. Now the couch & TV is not my best friend!! I hardly ever sit down anymore, I'm up & staying busy. By taking pristiq for 3-4yrs. it seems like I went thru' life in a fog. My head is clearing, but the "brain zaps" are still with me, less & less tho'.

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Karen, I was right where you are! I took Pritiq for five years.Before the drug, I was a happy go lucky type of person. Very active. Then I suffered a loss of a loved one and shortly after had a total hysterectomy. My PCM put me on this drug and it did help me. But after year three I had gained forty pounds and was just not my self. I couldn't loss the weight and I didn't want to leave the house. I'll do it tomorrow became my motto. but, tomorrow never came. I made two attempts to get of this drug and then I found this site. After reading everyone's experience I knew I was doing the right thing for me. I started by cutting 50mg in half for two weeks with very little side effects. on the third week I cut it again to a fourth. I did start having a sick stomach, dizzy and fuzziness, I took time off of work then and went cold turkey from there. On day three of cold turkey I stared to feel like my ole self. I literally was happy. and felt the feeling of happiness! I continued with the fuzziness for a few more days but, everyday is better. Did I tell you that as we speak I am fifty pounds over weight and I have high cholesterol. I am taking my life back and I am already losing the weight so yes I think I am a success story and you can be too!

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