I was on the 50 mg Pristiq, and I discussed tapering off with my doc. (It’s important to note that I only use minimum dosages of antidepressants for maintenance, and haven’t suffered a major depressive episode for at least 20 years. It’s quite possible that I don’t need the meds anymore.) Doc recommended against cutting the pills in half, but encouraged me to try taking it on alternate days. He said if I noticed any depressive symptoms, resume daily use. I started tapering off in mid-December, and I’m now taking it every third day. I’ll probably go to once every four days and then stop entirely. I’ve had no ill effects.