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Fecal Microbiota Transplant (FMT)

Inflammatory Bowel Disease (IBD) | Last Active: Oct 14, 2024 | Replies (81)

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Profile picture for chatticathi @chatticathi

Anyone had Fecal Microbiota Transplant (FMT) for C Difficile? I dont know where to open this topic, not cancer, should I do it or not, 5 bouts of c diff in 2021, 3 hospital stays, 1 c diff now, vancomycin for 6 months, off it for 2 weeks, that's when I got c diff again, now, what the hell to do, I'm 75 and terrified

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Replies to "Anyone had Fecal Microbiota Transplant (FMT) for C Difficile? I dont know where to open this..."

Welcome @chatticathi. You have been through a lot and I can imagine you've had enough and are scared.
I moved your question to the Digestive Health group where members are talking about c difficile and fecal microbiota transplant (FMT). Members like @sandyabbey @pines @nettecook @concernedmtnmom and @wendyw can share their experiences with FMT.

In this expert blog "C. Difficile Care at Mayo Clinic" https://connect.mayoclinic.org/blog/gastroenterology-and-gi-surgery/newsfeed-post/c-difficile-care-at-mayo-clinic/ Dr. Pardi, gastroenterologist, says patients with two or more recurrences, are considered high risk and, treatment may include:
- Prolonged courses of antibiotics
- A fecal microbiota transplant that restores healthy intestinal bacteria by placing another healthy person's (donor) stool in your colon, using a scope or tube. Research has shown fecal microbiota transplant for C. diff has a success rate higher than 90 percent.
- An intravenous infusion of an antibody called bezlotoxumab may be helpful in certain situations.

Is your doctor suggesting FMT for you?

Digestive healthcare of ga does fecal transplants. They are in fayetteville,ga. Just south off atlanta
Will change your life. Dr woods did mine in 2018.

That's good for you. I can't tolerate vancomycin, but the orange stuff is my daily thing, too.

@chatticathi I came down with cdiff in September, 2018. Spent 8 days in the hospital and lost 14 lbs. I was put on vancomycin every time and after the 3rd bout with cdiff, I had the fmt in March, 2019. It was the best decision ever! I still can't gain back the weight I lost, but so far, so good. I took clindamycin for a tooth abcess and was told that is what gave me cdiff. Several people on here also said clindamycin gave them cdiff. If you look up clindamycin and cdiff, they are directly related. If I were you, I would find another doctor to get the fmt. If you have any questions, feel free to ask me.

Glad to hear your. In a better place, vancomycin oral is working for me and I have to get off sometime, it's been 8 months daily and I drink a powder to keep bowel formed and that works and here I am!

I have had c.diff ten times over the last five years. I’ve taken Vancomycin, Dificid, two rounds of tapering Vancomycin, and a Zinplava infusion. Both my gastroenterologist and infectious disease doctors have recommended a fecal transplant. I have a redundant colon which prevents a complete colonoscopy. Can a fecal transplant be done in a redundant colon? If so, does it affect the success rate of the fecal transplant?

The FDA has a black box warning in the prescribing information for clindamycin (Cleocin). That represents the highest alert for physicians and patients about this antibiotic. It says in part:

“Because clindamycin hydrochloride therapy has been associated with severe colitis which may end fatally, it should be reserved for serious infections where less toxic antimicrobial agents are inappropriate…”
https://www.peoplespharmacy.com/articles/clindamycin-and-c-diff-infection-a-devils-ride

I had an FMT about 3 months ago and am doing very well. All cdiff symptoms gone. It is a free study being done by the Metropolitan Infectious Disease Center in Burr Ridge, IL, and they pay me...I am so grateful I found them, my life was going downhill... Good luck....

I was hospitalized for 16 Days in 2020 for severe Cdiff, Toxic Megacolon, Lymphocytic Colitis. Dr's were considering Surgery .
I was started on Flagyl IV, Vancomycin IV for several days. Neither seemed to be making a difference. Then my Infectious Disease Doctor started Dificid. Within 2-3 days I was significantly better. I was released having lost approximately 20 lbs. I was instructed to finish my Dificid at Home and come to the ID Dr for an IV on Zinplava (a very expensive Monoclonal Antibody Medicine-(Had to be approved by Medicare before they would pay for it). I then went for my First FMT ON 1-28-21. I did fairly well until January 2022, when I had another episode of Cdiff. Took another round of Dificid at home per my Infectious Disease (ID) Doctor. He said since my Stools were fairly normal, no FMT this time.
Again In April 2022 I had another Cdiff episode. Was put on Dificid again. Also had Second FMT , an attempted to take 2nd round of Zinplava and had a bad reaction after IV first started so the ID Doc stopped.

Fast forward to August 24th 2022 another Cdiff episode. Back on Dificid for 10 days. No Zinplava this time . Went for 3rd FMT on September 9th, 2022. So far so good. But really beginning to wonder if there is ever an ending point to this awful Disease.
FYI, my Gastroenterologist was in agreement to all this Treatment the whole way through. Sorry so long, but it's been a long road just to this point. Anyone else experienced this seemingly never-ending saga with their Cdiff?
I have tried all sorts of Dietary ideas. It really doesn't seem to make any difference what I eat the end result is always the same. Cdiff again.

I have been considering a fecal transplant. Do I need to contact a doctor now before I get c-diff again? Does c-diff need to be active to have the transplant? Any information you have would greatly be appreciated. Thank you.