Post prostatectomy: What do rising PSA levels mean?

I agree with the other comment that it is no reason to panic, but you should learn the facts and work with your doctor to come to the best resolution. I had a radical prostatectomy in December of 2000 at the age of 55. My Gleason score was 7 (4+3) although there was some debate about it being 8. My psa was never less than 0.1, but was around 0.11 or 0.12 (don't think people use the more sensitive readings much any more). I thought I was done with prostate cancer, but then in 2015 it went to 0.15 and in 2016 to 0.26. There was one questionable margin from the surgery so my doctor thought the recurrence might be local. I had bone scans which showed nothing and the thinking was that the recurrence was in the prostate bed. I had 6 months of ADT starting in March of 2017 and 7 1/2 weeks of radiation which ended in October of 2017. My psa is now less than 0.1 and I had no permanent affects from the treatments and am back to not worrying about prostate cancer at 76. Hopefully this is just a small bump in the road for you like it was for me.

My dad was diagnosed to be Prostate cancer in 2018.11 and he took the surgery right away. After that he was treated for 2 years by Gesorelin. from end of 2020 he stopped the treatment according to doctor's advice and then yesterday when he did the routine check the PSA is back to 0.11.
Wondering is it because there are bad cell not cleared during the surgery? Is it very common to have PSA back after stopping ADT?

Welcome Jerry, I moved your question about rising PSA levels after surgery and treatment to this existing discussion where @hoard had a similar situation. I encourage you to read through the posts in the discussion.
- Post prostatectomy: What do rising PSA levels mean? https://connect.mayoclinic.org/discussion/post-prostatectomy/

And this related discussion
- Detectable PSA 9 years post prostatectomy https://connect.mayoclinic.org/discussion/detectable-psa-9-years-post-prostatectomy/

There are several reasons why one's PSA level may rise after being stable for a time. This article explains it well:
– PSA levels after prostatectomy https://www.medicalnewstoday.com/articles/323899.php

Has your dad had a consult with his oncologist since getting his PSA reading? Will other tests be done?

I had a Radical Retro Pubic Prostatectomy August 2021
The PSA 3 months after was 0.01. I had a routine physical in December and the lab work showed the PSA now is 0.05 a 400% increase. I messaged the surgeon at Duke Cancer Center who will do another set of labs the first part of March. I was told that 0.05 is still considered undetectable. I am concerned with the sharp rise in just a month, Should I be concerned? I also had a Decipher genetic test, that said I was intermediate risk for a reoccurrence. The only thing on the test that I saw as a red flag was the positive result for Perineural invasion, meaning that cancer was detected in the nerves within the prostate. Can anyone shed any light or guidance on this?

Welcome @dpybarra, you'll notice that I moved your message to this existing discussion where @hoard was asking the same questions. I encourage you to read through the sage advice from fellow members
- Post prostatectomy: What do rising PSA levels mean? https://connect.mayoclinic.org/discussion/post-prostatectomy/

As you likely know, the PSA test alone is not enough to determine cause or next steps. Your doctor will likely order additional tests or followup in a few months with another PSA test. Do you have a followup appointment schedule with your oncologist?

Yes in the first week of March, this will be the second 3 month labs and follow up.

I have been Cancer free since my surgery removal of Prostate in July 2019. I have maintained <0.1 and as low as <0.02. still at this as of Jan 25,2022. I had a VA physical, and they do an ultra-sensitive PSA test Test Before in Dec 2020 was 0.008 this recent test is 0.016. Do PSA levels go up and down? I do not think Cancer is back My Path was very good from Surgery. No SV, Lym node Invasion Clear Margins, contained to the Prostate and Capsule. should I be alarmed!!

Hello, @fmcallister1954 Yes, it's scary when tests come back with a slightly higher PSA and I understand your alarm. My brother is being followed for prostate cancer (prostatectomy in 2020) and we've had many discussions about his treatment and what the PSA levels mean. I've been treated for uterine cancer and I also know how frightening it is to get back results that you did not expect. While you'd hope that the PSA number is exact and reliable there are many reasons why the number can change. This link from the American Cancer Society explains the fluctuations:

Are you being followed by an oncologist or the surgeon at the VA? How often do get a PSA? You mention a PSA test done in December 2020. And this new test is a year later. If you were my brother, I'd tell him to call the doctor who is following him and ask about this new PSA result. I would want to know the plan - should the PSA be repeated in 3 or 4 months to see if it changes?

Would you please come back here and let me know what you find out from your doctor?

No Oncologist is involved yet!! Contacted my Urologist and told him, has not responded yet, I am still considered < 0.02 very low. @ 0.016 that only 16 above 0.000 or none at all so it is very early yet. I will no doubt get rechecked in 3months.

Fmcallister, your question about whether you should be alarmed at rising PSA levels after prostatectomy is commonly asked in the forum. For that reason, I have moved your question to this discussion:

- Post prostatectomy: What do rising PSA levels mean? https://connect.mayoclinic.org/discussion/post-prostatectomy/

I strongly encourage you to read through the discussion to see the helpful advice from fellow prostate cancer members. The short answer is "No, you should not be alarmed. But yes, it should be noted by your team and discussed."

Has your urologist been in touch? What did you learn?