High platelet count: What does this mean?

Posted by carlsonte @carlsonte, Feb 27, 2019

My son, who is 46, has an elevated platelet count of 700,000 to 870,000. It has went on for over four years and is only being monitored. Is there more testing other than blood tests that can be done? What are the concerns a person should have with this elevated count?

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@snacker1206

Hi! My regular dr wasn't worried when my platelets were high for 4 years, just told me to take a baby aspirin every day. My counts went 485/520/540/585/618/ and now have been 638 for a year. I went maybe once a year to a hematologist/oncologist anyway for high iron/hereditary hemochromatosis so I asked him what he thought. He decided it was time to run some genetic mutation tests and also some tests to rule out conditions like rheumatoid arthritis. FYI - make sure your dr gets prior auth for these tests bc mine did not and I owed over $2k for them... All these tests came back negative, which was a relief but my platelets continued to rise so he ordered a bone marrow biopsy this January. The results showed abnormal platelets but no fibrosis or cancer. The radiologist who examined the sample asked my hemo if he'd done mutation tests and it turns out he forgot one! She ran it, and it came back positive for CALR mutation type 1. It was crushing bc I had done all my Google research and I thought it was a death sentence. But I saw an MPN specialist and he put my mind at ease, and actually told me NOT to take a daily aspirin. He said the gym/lifting weights is my medicine for now and he would go off my symptoms (which I have minimal symptoms). Anyway, yes - If I were you I would seek out a local hemotologist/oncologist (don't freak out about the oncology part) and be your own advocate - tell them you want tests run to rule out things (but get prior auth first!!!) It could be that your periods are so heavy that you've become anemic and your platelets can react to that - that would be a good outcome! Good luck and prayers to you!

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I have a high count of 750 with JAK ET currently on Hydroxyurea for a month now. Along with Ondansetron for sickness. Get blood work again in a week. Hope they come down.

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@anonymo77500222

I have a high count of 750 with JAK ET currently on Hydroxyurea for a month now. Along with Ondansetron for sickness. Get blood work again in a week. Hope they come down.

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How were the results of your blood work, Anonymo? Did the values come down?

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Not seeing any research on Elevated platelet counts preindicators for Cancer I can verify this one myself I kept seeing research being done in other countries but not here? It looks to be very promising.

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@toepeekun

Not seeing any research on Elevated platelet counts preindicators for Cancer I can verify this one myself I kept seeing research being done in other countries but not here? It looks to be very promising.

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Good morning @toepeekun. Mild to moderately elevated platelet counts are commonly seen when chronic inflammation is present. In other cases a high platelet count can signal a more serious blood problem known as a myeloproliferative disorder.
It sounds like you’re familiar with this. Have you been diagnosed with thrombocytosis or myeloproliferative neoplasm? Are you in treatment at this time?

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@toepeekun

Not seeing any research on Elevated platelet counts preindicators for Cancer I can verify this one myself I kept seeing research being done in other countries but not here? It looks to be very promising.

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Had surgery invasive breast cancer going into treatment just trying to educate myself looking through my own lab work

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@toepeekun

Not seeing any research on Elevated platelet counts preindicators for Cancer I can verify this one myself I kept seeing research being done in other countries but not here? It looks to be very promising.

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Hey @toepeekun, you might notice that I moved your post to a discussion talking about high platelet counts so you can bond with other members going through similar situations.
What treatment are you entering?

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@toepeekun

Had surgery invasive breast cancer going into treatment just trying to educate myself looking through my own lab work

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Oh golly, I’m sorry about your cancer diagnosis. That’s always earth shattering isn’t it? But education is power so I know you want to find out as much as you can. If you’re having chemo treatments, that can affect your blood counts, including your platelet levels. They can be very erratic during treatment.

Looking through results of lab work, if you’re not familiar with all the terms and what each number represents, can be a little bewildering. From experience, I know it’s easy to go off searching for possible answers. But we can also misinterpret things too, Have you discussed your blood work with your oncologist?
Do you have any specific numbers you’re seeing that you want to know more about? You mentioned platelets. Are your counts elevated?

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I had thrombocytopenia with a very low platelet count (opposite of low is high (thrombocythaemia). For me, I was making plenty of platelets, but my spleen was killing them. I had to have a splenectomy at 28. Now 30 yrs. later I am in the 5 - 700 area and my Oncologist is not concerned, even though I had a splenectomy and a Liver transplant. For some it becomes a norm, for others be on top of your blood work and get to know what each of them mean and how they affect your body. Do you have other abnormal results? Any symptoms?

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I've dealt with a CALR mutation for 2.5 yrs, have (seasonal) 2 Hematologists, tried to remain a 500mg Hydroxy daily but platelets have exceeded 1 million a couple times so I've been on 1,000, losing hair! I'm currently in the 500's. I've had an ablation last year so I'm on lo dose and a blood thinner, I'm worried about a brain bleed? 74, thin, exercise over an hour daily.

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Some people and acquaintances were saying a high white blood count of 92000 - 105000 shows you could have a stronger immune system which is much different than a very low white blood count; how can this be true? EAM

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