Welcome, @crabman. I add your question about AREDS 2 and muscle pain to the Eye Conditions group (https://connect.mayoclinic.org/group/eye-conditions/) as well.

Members like @johnbishop @gagirl2019 @bonitav @georgiegirl88 @imallears @pacer3702 @lioness @firespooks and others have been talking about side effects in this related discussion:
- AREDS 2 and side effects https://connect.mayoclinic.org/discussion/areds/

I've seen that muscle weakness is a known side effect. Crabman, it sounds more like you have pain. Would you describe it as cramping or weakness?