1. < Breast Cancer

Triple Negative Breast Cancer: What treatments are you having?

Posted by thielmann1 @thielmann1, Dec 9, 2021

I have just been diagnosed with Triple Negative Breast Cancer after having Estrogen Positive Breast Cancer for 21 years. Is anyone familiar with this diagnosis and treatment that you are having for it?

Interested in more discussions like this? Go to the Breast Cancer Support Group.

Mentor
Chris, Volunteer Mentor | @auntieoakley | Dec 21, 2021
In reply to @medical01 "The clinical manifestation of triple-negative breast cancer is an aggressive course, with a higher risk of..." + (show)
@medical01

The clinical manifestation of triple-negative breast cancer is an aggressive course, with a higher risk of distant metastasis, a higher chance of visceral metastasis than bone metastasis, and a higher chance of brain metastasis. The risk of distant metastasis of triple-negative breast cancer reaches its peak at 3 years, and may decrease thereafter. The median tumor size of triple-negative breast cancer is 2 cm, and 50% have lymph node metastasis. The histological grade of this type of breast cancer is mostly grade 3, and the proportion of cell proliferation is relatively high.

Treatment
There are no specific treatment guidelines for triple-negative breast cancer. Therefore, its treatment is generally carried out according to the conventional standard treatment of breast cancer.
1. Chemotherapy
Compared with other types of breast cancer, chemotherapy is more effective for triple-negative breast cancer, but if it is just a conventional standard treatment, the prognosis is still very poor.
2. Adjuvant chemotherapy
FEC sequential docetaxel chemotherapy has a better response. Taxanes have a certain effect on triple-negative breast cancer. Platinum drugs may be more effective in triple-negative breast cancer. Cisplatin neoadjuvant chemotherapy is quite effective.

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Thank you for the TNBC 101 class, I think it helps us all to have more information. Maybe in the future research can solve the problem of not having a druggable target in TNBC, and make this an easier path for patients and provide clearer treatment plans for clinicians. Without a clear path to move forward it is just a stress inducing diagnosis for everyone.

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Mentor
Chris, Volunteer Mentor | @auntieoakley | Dec 21, 2021
In reply to @mlk "im in very similar situation.had er pos 21years ago...now surg for 3Nbc...now margins/nodes all clear...not anxious..." + (show)
@mlk

im in very similar situation.had er pos 21years ago...now surg for 3Nbc...now margins/nodes all clear...not anxious to do rec chemo prefer holistic supps,diet,exercise

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This is just heartbreaking, I know his happens because we have all been talking about it, but to feel like you beat it and have all that time go by and then be diagnosed with TNBC. Deep sigh!
Please take some deep breaths and get truly informed, before you decide. I know the thought of going through chemo again is hard. I personally have had to make this decision a couple times with her2+. Everyone has to choose their own path but the best thing my friend the surgeon who saved me in my 30’s ever told me was “The only good decision is a fully informed decision.” Make sure you have all the information and then make your decision. I will certainly be thinking about you. Has your doctor talked to about what he would recommend yet? Have you been information gathering?

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Moderator
Colleen Young, Connect Director | @colleenyoung | Dec 22, 2021
In reply to @imlistening21 "Hello, has anyone gone through the oral chemo (Xeloda) 8 round (6 mos) regimen? It’s a..." + (show)
@imlistening21

Hello, has anyone gone through the oral chemo (Xeloda) 8 round (6 mos) regimen? It’s a fairly new treatment according to my oncologist, and has shown to reduce chances of recurrence but it’s a strong drug. I was diagnosed in April w Stage 2B TNBC, HERS-Negative. Had AC-T chemo by infusion but had to stop early due to neuropathy, after a few weeks had surgery to remove tumor and 5 sentinel lymph nodes with clear margins so was supposedly cancer free but there was still cancer in the tumor that was removed. This was followed by 36 radiation treatments, just completed last week. But because there was active cancer left in the tumor, I’m a candidate for this additional oral chemo. I’m worried about the side effects, especially the hand/foot syndrome which sounds very painful and debilitating. I’m in my 60s with other medical conditions so am trying to weigh the benefits vs risks of taking Xeloda. Sounds like there’s an equal argument for doing it or not, in my particular case, but I need to decide fairly soon or it will not be as effective. Really struggling to decide what to do. Anyone had a similar scenario? Comments? Thanks!

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Imlistening, you might also be interested in this related discussion that @pattycron started and others like @kk57 @old @omaegg @jackiestack took part in.

- Capecitabine (Xeloda) side effects: how do you manage them? https://connect.mayoclinic.org/discussion/xeloda-oral-chemo/

Patty too has triple negative breast cancer and had chemo, surgery and radiation.

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Mentor
Chris, Volunteer Mentor | @auntieoakley | Dec 24, 2021

Hope on the horizon.💕 there is a stage 2 trial being conducted and studied right now. There is an inducible target that can then be targeted with a new compound along side docetaxel. This is showing promising results in a very small trial. This is researchers finding a druggable target. I can’t say it will work out but I can say this is exactly the kind of work that is needed and ongoing for TNBC.

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gbnana | @gbnana | Jan 5, 2022

At my oncologist yesterday and found out my new tumour is triple neg. I am 70 and doc talked with me about the effects of the type of chemo that would be used to treat this. She said anyone 65+ needs to understand this chemo really knocks you down and sometimes you can't get back up! Looked at the current stats with or without this chemo and decided I will NOT have chemo. I believe it is the right decision

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Mentor
Chris, Volunteer Mentor | @auntieoakley | Jan 6, 2022

I know that this is a very difficult decision. I know you have agonized from the time you were diagnosed. We all have the right to make our own choices about treatment. I do hope you have a doctor you trust. Do you have family support?

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olg1 | @olg1 | Jan 6, 2022

I was diagnosed with triple negative invasive carcinoma the breast at age 75. We wanted to give me chemo but I couldn’t get an egg because of the worker shortage trade 15 agencies they were all short of people I did the radiation I also did alternative treatment and Quincy mass with a Chinese acupuncturist who has healed people of cancer. I don’t know where you’re located but he’s located in Boston Quincy mass his name is Tom Rhen.If you don’t have any alternative to chemo you might try that and visualization I will keep you in my prayers

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2 replies
olg1 | @olg1 | Jan 6, 2022
In reply to @olg1 "I was diagnosed with triple negative invasive carcinoma the breast at age 75. We wanted to..." + (show)
@olg1

I was diagnosed with triple negative invasive carcinoma the breast at age 75. We wanted to give me chemo but I couldn’t get an egg because of the worker shortage trade 15 agencies they were all short of people I did the radiation I also did alternative treatment and Quincy mass with a Chinese acupuncturist who has healed people of cancer. I don’t know where you’re located but he’s located in Boston Quincy mass his name is Tom Rhen.If you don’t have any alternative to chemo you might try that and visualization I will keep you in my prayers

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Sorry for the typo. It is Tom Tam

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Mentor
Chris, Volunteer Mentor | @auntieoakley | Jan 6, 2022
In reply to @olg1 "I was diagnosed with triple negative invasive carcinoma the breast at age 75. We wanted to..." + (show)
@olg1

I was diagnosed with triple negative invasive carcinoma the breast at age 75. We wanted to give me chemo but I couldn’t get an egg because of the worker shortage trade 15 agencies they were all short of people I did the radiation I also did alternative treatment and Quincy mass with a Chinese acupuncturist who has healed people of cancer. I don’t know where you’re located but he’s located in Boston Quincy mass his name is Tom Rhen.If you don’t have any alternative to chemo you might try that and visualization I will keep you in my prayers

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I know you have had a very difficult journey, I thought you might benefit from this.
https://connect.mayoclinic.org/discussion/stress-management-for-cancer-free-online-course-from-mayo/

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mlk | @mlk | Jan 7, 2022

I just had a mastectomy, my 1 cm tumor was 3N, but otherwise am ALL CLEAR!!! I DO NOT want to do chemo...I used to live in Mass. and would love to consult with that acupuncturist. thank you. not healing well due to too much radiation 3 yrs ago (IORT and adjutant)

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