Have you tried the new Protocol 525 product for neuropathy relief?

Posted by John, Volunteer Mentor @johnbishop, Apr 21, 2020

I have used the original version of the Protocol 525 product (https://theprotocolworks.com/) since 2016. I have idiopathic small fiber peripheral neuropathy with the only symptom being numbness in both legs. When I started taking the protocol, the numbness was just below my knees. After 2 months, the numbness seems to be just above the ankles which is subjective on my part with no additional testing. I do feel it is a win-win for me as my neuropathy has not progressed like I was told it would by the neurologist. I have continued taking the protocol in hopes that it may continue to roll back the numbness symptoms. I have noticed some new feeling in my feet in the last 2 months. Some feeling has returned to me feet and they seem to feel better lately although I still have the numbness – hard to describe the difference.

The Protocol 525 is not a cure for neuropathy. It treats the pain and discomfort symptoms of neuropathy without the drugs which have their own side effects. Have you tried the Protocol 525 or the original protocol? Did it help? If yes, how? If no, please share.

Note: I have no commercial investment in the protocol and I am sharing this information as someone who has found some degree of relief using this combination of supplements. I also discussed these supplements with my Mayo primary care team before I started taking them. The care team sent them to the pharmacist for review who did not have any major concerns for me taking them.

*** Edited Oct 3, 2023 ***
For more information and a list of the ingredients, please see the frequently asked questions on the Protocol's website here - https://theprotocolworks.com/faq/.

Interested in more discussions like this? Go to the Neuropathy Support Group.

@lincolned

Hi John, Based on what i've picked up from you and a few other credible sources of info, i think i will try the Protocol 525, despite the fact that i'm hesitant because of ALA ingredient and my hypo thyroid/levothyroxin issue which i have read is a reason to be careful. I have consulted my endocrinologist and we will do a blood test in about 3 months from the start of the program. Since my sensory nerve neuropathy has become quite aggressive of late, spreading to my upper limbs and back and chest for no apparent reason, I have to try something, whatever the cost. Thanks for your input on this product.

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@lincolned I hope it works for you and provides some relief. Can you keep us updated after you have had a chance to try it?

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@johnbishop

Just a quick note, I don't believe it's a matter of if they have ever heard of this substance. I did run all of the original supplements in the current 525 product when we were ordering them separately. It was over 20 pills daily for all of the supplements and vitamins we were taking in the Facebook group. Because it was difficult for a lot of members to take so many pills, the person who started the group, Bob Diamond, worked with a local pharmaceutical company to see if we could combine some of the vitamins into a smaller number of pills. Hence the name 525 (5 capsules in the morning, 2 at noon, 5 in the evening vs the 20+ pills). The cost is close to the same amount we were paying through Amazon to purchase the individual items, about $6.50/day. Another benefit is that the different items were ordered when you ran out and they typically ran out at different times during the month due to how many pills were in each product.

All of the products have scientific evidence of benefiting/helping nerve regeneration and health. I ran the original list of supplements by my Mayo doctor who sent them to a pharmacist for their thoughts and she didn't have an issue with them. Most of the ingredients are listed on the Foundation for Peripheral Neuropathy here: https://29fvx519grkh3bdqrc16zioc-wpengine.netdna-ssl.com/wp-content/uploads/2016/10/Supplements-Not-highlighted.pdf. Here's another article that lists a lot of the same supplements - https://www.healthline.com/health/neuropathy-supplements

I started taking the Protocol 525 in Sept 2016 before it became the Protocol 525 and we ordered everything through Amazon and sometimes the manufacturer's website if the price was better. I only have the numbness and do feel that it has slowed or possibly stopped the progression of my idiopathic small fiber PN as the numbness was close to the knees in both legs when I started and within a few months of taking the supplements it seemed to be just above my ankles. Since I had tried so many different things with very little help, this was a big deal for me. I realize that this is a little subjective on my part and it may not work for everyone but if you've tried everything else it may be worthwhile to try. I would certainly run it by my doctor first just to make sure there are no interactions with any other medications you may be taking.

The ingredients for the Protocol 525 are listed under the frequently asked questions on their site here: https://theprotocol525.com/faq/. Good luck whatever you decide. I hope you find something that helps!

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1. Alcohol
2. Seafood
3. Brown Rice
4. Gluten
5. Vitamin B6
6. Starches and Carbohydrates
Hi again, I came across this list of things that can aggrevate neuropathy. in that seafood is on the list, does it rule out taking fish oil as part of the Protocol program? I think i have had a reaction to salmon.

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@johnbishop

@lincolned I hope it works for you and provides some relief. Can you keep us updated after you have had a chance to try it?

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yes, I will keep you updated. I am about to order it now.

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@lincolned

Quick Navigation Hide
1. Alcohol
2. Seafood
3. Brown Rice
4. Gluten
5. Vitamin B6
6. Starches and Carbohydrates
Hi again, I came across this list of things that can aggrevate neuropathy. in that seafood is on the list, does it rule out taking fish oil as part of the Protocol program? I think i have had a reaction to salmon.

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I don't think so. The Omega 3 fish oil capsules 1000 mg (EPA 330 mg. DHA 220 mg) are part of the Protocol as well as the Hemp Seed Oil which provides plant based Omega 3 and 6. I like taking it in capsule form as I used to have to take 2 tsps daily of fish oil and while I'm not really alergic, I don't like any seafood. It doesn't agree with me 😁

Here's some info on the topic -- Omega-3 polyunsaturated fatty acid supplementation for improving peripheral nerve health: protocol for a systematic review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875591/

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This sounds very interesting. How does this protocol work if it doesn’t involve meds? Thank you.

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@banksnc49

This sounds very interesting. How does this protocol work if it doesn’t involve meds? Thank you.

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This pretty much sums it up - https://theprotocol525.com/faq/

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Thank you John. I’ll check it out b

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John, checking out P525: couple questions: are there specific foods or medication you should avoid with P525? My feet don’t burn they are ice cold. Will P525 help me? How much water should you drink daily with it? Thanks for all of your information, bcool123

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@bcool123

John, checking out P525: couple questions: are there specific foods or medication you should avoid with P525? My feet don’t burn they are ice cold. Will P525 help me? How much water should you drink daily with it? Thanks for all of your information, bcool123

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@bcool123 - Each of us are different so I can only share my experience with the Protocol 525. It has helped me slow or possibly stop the progression of my neuropathy. I have more feeling in my feet than I did when I started using the supplements in 2016 that were combined into the Protocol 525 product and my neuropathy has not gotten any worse. My feet still feel cold at times but I do what I can to warm them up and protect them as much as I can.

The Protocol 525 FAQs statement on how much water you should drink with the 525 -- "...We recommend that 80 to 100 ounces of water be consumed when using The Protocol 525 so the body can not only properly absorb the additional nutrients being offered to it, but discard the unneeded excess through natural processing in the kidneys. Hydrated cells and organs operate at their best, and that is the condition that we strive to achieve." -- https://theprotocol525.com/faq/. Here are a couple of more sites on the topic:

-- Water: How much should you drink every day?: https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/water/art-20044256
-- How Much Water You Need to Drink: https://www.healthline.com/health/how-much-water-should-I-drink

Everyone should eat a healthy diet, protocol or no protocol. 🙂 I try to avoid sugar and alcohol because they definitely do not help if you have neuropathy. Here's some good information from the Foundation for Peripheral Neuropathy - https://www.foundationforpn.org/living-well/lifestyle/nutrition/

I really try to drink a minimum of 64 oz of water daily in addition to coffee, tea or other liquids I drink during the day. Sometimes I get it done and sometimes I fall short but get up the next day and try it again. I think hydration is really important for everyone.

Good luck on whatever you decide and hope you find some relief!

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John, thank you for your input in the websites. I’m looking into all of them, bcool123

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