Hi everyone, I was diagnosed with PV in Feb 2020. I started pegasys (initially 45, later 90mcg / week). I still had to get regular phelebotomies --- had maybe 10 of them in 6 months. My HCT kept going above 45 pretty fast. Also raising the Pegasys dose to 90mcg after 4 weeks seemingly had no effect. I started ketogenic diet through the encouragement of my mom, to lose weight. The immediate effect on my blood markers was very surprising. My HCT remained below 45 (42.7 , 42.9) in the last two 3-weeks-apart blood draws. Also my WBC (6.8 to 5.1-5.3) and platelets (550-600 to 490) came down a little bit --- again, for the first time.

Keto worked like magic for me. Also Pegasys could've kicked in after ~4 months, but my bloods were so resistant until I started keto! If anything, the two turned out to be a surprisingly good combination.

I want to mention I eat a fairly healthy ketogenic diet. Lots of veggies. Limited meat (maybe every 2 days), mostly fish. Mediterranean style.

As a bonus content, let me share this paper regarding the effects of ketosis on other cancers. While not a guarantee, it's found to be useful for most cancer types to slow the growth of tumors.
Ketogenic diet in cancer therapy, 2018
10.18632/aging.101382