Hello @telios and welcome to Mayo Clinic Connect. I'm so glad that you joined this discussion group to help your wife. It sounds as if she has a lot of uncomfortable symptoms with constipation being the worst. Constipation is a problem for most of us who have PD.

If you could share a bit more I'm wondering how long ago your wife was diagnosed with PD? Have her doctors suggested anything for constipation? Many of us have found fiber supplements (like Metamucil) helpful as well as stool softeners (Miralax or Colace). I use both products daily.

We currently have a Connect discussion group all about PD and constipation. Here is the link, https://connect.mayoclinic.org/discussion/constipation-and-parkinsons. You can read what others are saying and doing about this problem.

Also, here is an article from the Parkinson's Foundation website on the topic of constipation, https://www.parkinson.org/Understanding-Parkinsons/Symptoms/Non-Movement-Symptoms/Gastrointestinal-Issues, In this article, you will read that nausea and swallowing problems can also be a problem. Since your wife has been losing a lot of weight perhaps this is a problem for her as well?

You also mentioned that she has spasms. Are the spasms in the abdominal region?

I look forward to hearing from you again. Will you post an update?