I am sure you have all tried to do some research on this issue, and found as I did, an absence of guidance. So I turned to my trusty VAERS database. With about 500,000 reports of adverse events out of 340,000,000 vaccinations, if there's a problem, it's going to show up there. So there were 7 reports of reactions POSSIBLY linked to MTHFR, including 3 hospitalizations and 0 deaths. Since as many as 30-40% of the population has the C677T mutation, it is reasonable to surmise that a lot of people with MTHFR have been vaccinated, so it looks like a very rare side effect.

In contrast, a number of severe Covid cases, including hospitalizations have been linked to the mutation in some groups, see: https://onlinelibrary.wiley.com/doi/10.1002/jcla.23798 According to the article, the gene, and a specific mutation (C677T) they cite, can actually predict a higher chance of severe Covid infection.

In this case, absent other health issues, or medical advice to avoid vaccination, it looks like vaccination is a safer choice than a chance of infection...but only you and your daughter can decide.

Sue

I have the MTFHR gene. I have had blood clots twice (I am 51 years old.) I was taking eliquis, and was recommended to get the covid vaccine, and reassured the eliquis would prevent any blood clots. My doctor was WRONG. This time I got a blood clot from groin to ankle in the right leg 1 week after my 2nd moderna vaccine. I ended up on 120mg of lovenox TWICE a day (normal dose is 30mg), in addition to Warfrin (which varries depending on labs.) Right now I have completed 2 weeks of lovenox treatments with a stomach that looks like it has been hanging in a meat factory from incredible bruising and hematomas. My warfrin is 7.5mg 5 days a week and 10mg 2 days a week. My INR is tested twice a week, so this is subject to change. I will NOT get the booster.

My daughter also has the MTHFR and has had ongoing health issues for 2 years is also required to get the vaccine. I personally suffered a frozen shoulder after receiving the vaccine and am concerned about my daughter’s response.