My 73 husband started feeling extreme tiredness and week in his legs a few months ago. He has no energy, nor does he have any strength to accomplish household chores. He has also lost around 15 lbs. His appetite has decreased as it just takes to much energy to fix foods or eat. After visits to the Dr. he was immediately removed from Lisinopril. He does take multiple blood pressure meds though I believe this was given as a cholesterol med. He has been on Lisinopril for about a year. He recently had a stress test which was fine with quick cardiac recovery. Results of blood tests was elevated PSA numbers and high protein in the blood. These tests are being re-ran to see if they were a fluke or these numbers might bring up other concerns.. His EKG was normal... so no cardiac issues.. It is my understanding that Lisinopril can be the culprit...but how long can this affect you. its been a couple of months since he was removed from this medicine. I also understand that this is rare and not a common side effect of this medicine. We return to the urologist this week to get his test results again on his PSA numbers. Then in a couple of weeks we return to the other specialist on his testing. Hopefully this can be identified. Its hard to see your loved one go down hill so quickly.