Yes indeed, the mental state can be extremely difficult when the Grover's seems absolutely merciless in trying to make you unbearably miserable. I live in a state where marijuana has been legalized and they have dozens of different blends of the various strains for whatever objective you want to achieve. I don't know how effective this might be for one's mood, but I may have to give it a shot someday. As you said about the "try everything" approach when you are suffering badly, I do that too, and I am keeping the Amazon delivery drivers VERY busy. Best of luck!