I also have been taking Premarin happily for years, then suddenly, my insurance Blue Cross and their Pharmacy Express Scripts, denied coverage. They suggested i try Estradiol, but of course that would mean that I would have to go off Premarin, which I've been taking for 33 years. This would mean that at 81, I would suddenly be plunged into menopause. I work full time, travel, am happily married to a much younger many, am finishing my third book and my doctor told me that my health could be ruined by going off Premarin at my age. Why should I suddenly be condemned to an early death to save the drug companies money? Premarin may not be for everyone, but then why not find substitutes that prevent the ravages of menopause to older women allowing them to continue full lives? I notice that drug companies still pay for viagara. I'm in the process of finding a Canadian pharmacy with the full support of my doctor and I am beyond grateful to the Mayo Clinic for providing this forum.

I am curious to know what a Canadian pharmacy charges for a tube of Premarin. I recall being shocked some years ago when a tube of Premarin cost nearly $100. Subsequently, Estradiol was prescribed, and that's what I've been using twice a week since then, along with a pessary. I have had a problem with a sore and bleeding, but that has been attributed to the pessary.