Hi @missdi! I received my new heart 4 years ago and have had several changes to my meds. I was taken off of tacrolimus due to its negative effects on my kidney output. It also made my hair fall out! I hated that. I was placed on sirolimus which seems to be less toxic to my body with no real bad effects. I take prednisone every day and will do so probably for the rest of my life due to an underlying sarcoidosis illness that caused my heart failure. The prednisone has given me chipmunk cheeks that I can't get rid of and can make me edgy. I don't take many other drugs - I've been fortunate that way. I hope this helps. Take care.