@missdi Welcome to Mayo Connect! We are a communty of patients/famiy members/caregivers who share common experiences in our health journeys. We are not medical drs, and will not diagnose.

That said, as you mentioned, each person is different. My husband was transplanted almost 5 years ago, from a deceased donor. His immuno supressant meds have changed a few times. He continues to have labwork pulled every three months. It is my understanding it is not unusual to modify doses from time to time.

What is your concern about changing medications or doses?
Ginger