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Link between Seroquel and Heart Problems?

Mental Health | Last Active: Oct 26, 2023 | Replies (85)

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@jfe

My son struggles with schizoid effect disorder. He is currently on 300mg of serequel and takes the invega shot. His heart rate has gone to 140 and is steadily above 100. His doctor has said she wants him to start taking 150mg serequel instead of the 300mg. She said it would be okay to move from the 300 to 150 right away. I am concerned. I know we need to do something I just hope that the tapering from 300 to 150 is drastic???? Any thoughts???

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@jfe
Were it me I wouldnt reduce it 50% at any time. However, a 50% cut is usually easier when the dose is higher. A 50% cut when on a lower dose normally causes increased withdrawal effects.
Since large cuts frequently cause withdrawal symptoms personally I wouldn’t cut the dose by 50%. Also I wouldn’t skip days since its half life is only approximately 6 hours.
Good luck on whatever you decide,
Jake

Hi @jfe and welcome to Mayo Clinic Connect. I think you may be interested in the following discussion I have linked below as the member who started it was also taking 300 mg of Seroquel and tapered down quite a bit as well.

Getting off Seroquel - https://connect.mayoclinic.org/discussion/getting-off-of-seroquel/

If you or your son are concerned with the side effects of tapering. I would suggest asking the physician if he could taper at a slower rate.
Did she give any instruction as to what would constitute you calling and reporting side effects that may be harmful during that time?

I understand this may be a little late of a reply.

I know everyone here seems to be talking about tapering off Serequel, but I was on 800mg for about 8 years. When I decided to come off I stopped without tapering. I just threw the pills away and prepared for a crap time.

The withdrawal lasted about 3 days and after 2 weeks I was ready to continue construction work. For a family member. I'm sure it may not be the same for everyone else, but I can only speak to my own experience.

I'm definitely not a medical professional. But the choice was simple for me. Potentially fatal heart problems or a bad withdrawal.

To be honest it was a mild withdrawal in comparison to other drugs iv had to come off.