I stopped taking Premarin pills about 10 years ago and now in my late 60s. The pills definitely helped, but doctor didn't want me to continue long-term on them and so slowly weaned off them and have adjusted well. I continued to use the Premarin cream until just recently when I started using Estradiol cream when my insurance would no longer cover Premarin. So far the Estradiol has not measured up to the Premarin cream and may have to bite the bullet, go back to Premarin and pay for it out of my own pocket.