Dear Maria, after looking at your post, my history sounds so alike (depressio, OCD, 27 total ect's, and 12 years hunting,searching, and trying all different meds) Seraquel is one of the few I did not try. After 12 years I went to a Neuropsychiatrist. She went over my family mental health history, gave me LITHIUM for the first time ever and I have been taking it for 33 years! I know every body is different and not all meds work for everyone but Lithium is truly a GOD send for me. I believe HE has done a miracle for my mental health after all I've been through. My #1 suggestion is NEVER adjust your meds without approval from your Doctor--side effects can be worse than the original dose. #2-somehow find a doctor, psychiatrist who is willing to really work with you and your meds. #4 - Keep at it and don't ever give up. #5-Pray, pray, pray--God still works miracles in our lives. Then saturate your mind with Scripture from God's Word, also ask God to give you a specific verse to memorize that you can repeat in place of any troubling thoughts. Mine is Proverbs 3:5-6 - "Trust in the LORD with all your heart, lean not on your own understanding, acknowledge HIM in all your ways and HE will direct your paths." Maria, I will be praying for you every day around 8:00 am. Sharon