1. < Neuropathy

Old tricyclic antidepressant for nerve pain works well?

Posted by lorirenee1 @lorirenee1, Jun 22, 2020

I came across pain doc Ian Carroll's you tube video, and I am going to ask my pain doc to prescribe Desiprimine. It is an old time tri cyclic antidepressant and Dr. Carroll says it is beats all other meds for nerve pain. It is not readily prescribed because it is cheap, with little incentive for Big Pharma to push it. It can be measured in blood plasma to make sure it is at a therapeutic dosage, and is well tolerated. Young docs may not even know of it. I am going to try to attach the you tube video I saw, and about 41 minutes into the video, you will hear about Disiprimine. Here goes. My computer skills are lacking. https://youtu.be/v8CP-rfqp0s Wow! I did it. Please listen to this Doctor. His intelligence is palpable. Lori Renee

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Mentor
John, Volunteer Mentor | @johnbishop | Jun 22, 2020

Hi @lorirenee1, Thanks for creating the new discussion. Here's some more information on Desiprimine and similar drugs for treating neuropathic pain.

Antidepressants: Another weapon against chronic pain: https://www.mayoclinic.org/pain-medications/art-20045647

Tricyclic Antidepressants in Neuropathic Pain: The Good, the Bad, and the Potentially Ugly: https://www.pharmacytimes.com/contributor/kelsie-flynn-pharmd/2016/01/tricyclic-antidepressants-in-neuropathic-pain-the-good-the-bad-and-the-potentially-ugly

Nearly All Antidepressants for Chronic Pain Present Side-Effect Issues: https://www.uspharmacist.com/article/nearly-all-antidepressants-for-chronic-pain-present-sideeffect-issues

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1 reply
lorirenee1 | @lorirenee1 | Jun 22, 2020
In reply to @johnbishop "Hi @lorirenee1, Thanks for creating the new discussion. Here's some more information on Desiprimine and similar..." + (show)
@johnbishop

Hi @lorirenee1, Thanks for creating the new discussion. Here's some more information on Desiprimine and similar drugs for treating neuropathic pain.

Antidepressants: Another weapon against chronic pain: https://www.mayoclinic.org/pain-medications/art-20045647

Tricyclic Antidepressants in Neuropathic Pain: The Good, the Bad, and the Potentially Ugly: https://www.pharmacytimes.com/contributor/kelsie-flynn-pharmd/2016/01/tricyclic-antidepressants-in-neuropathic-pain-the-good-the-bad-and-the-potentially-ugly

Nearly All Antidepressants for Chronic Pain Present Side-Effect Issues: https://www.uspharmacist.com/article/nearly-all-antidepressants-for-chronic-pain-present-sideeffect-issues

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@johnbishop Thanks so much, John. You are consistently awesome!!!! Lori

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1 reply
Mentor
John, Volunteer Mentor | @johnbishop | Jun 22, 2020
In reply to @lorirenee1 "@johnbishop Thanks so much, John. You are consistently awesome!!!! Lori" + (show)
@lorirenee1

@johnbishop Thanks so much, John. You are consistently awesome!!!! Lori

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@lorirenee1 Aw Thanks Lori Renee 🙂 Hope you can let us know what your pain doc says and hopefully it will help alleviate your pain.

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Mentor
Jim, Volunteer Mentor | @jimhd | Jun 22, 2020

@lorirenee1 I tried desipramine, just before I started taking Imipramine in September last year. I think the pain was a little better, but I needed to urinate urgently, more times a day, up to 24 times. That was a pre-existing condition but was under control with Oxybutinin. Needless to say, I stopped that one.

Oxy was the third from the end of the pain specialist's list of medications to try. Next came Imipramine, which did really help for a few months.

Jim

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1 reply
lorirenee1 | @lorirenee1 | Jun 22, 2020
In reply to @jimhd "@lorirenee1 I tried desipramine, just before I started taking Imipramine in September last year. I think..." + (show)
@jimhd

@lorirenee1 I tried desipramine, just before I started taking Imipramine in September last year. I think the pain was a little better, but I needed to urinate urgently, more times a day, up to 24 times. That was a pre-existing condition but was under control with Oxybutinin. Needless to say, I stopped that one.

Oxy was the third from the end of the pain specialist's list of medications to try. Next came Imipramine, which did really help for a few months.

Jim

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@jimhd Hi Jim, This certainly was not the drug for you!!!! It just sounded promising on the video. Don't they all???? Lori

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Hank | @jesfactsmon | Jun 22, 2020

Lori, I like this Ian Carroll guy, he speaks in a straightforward understandable way. I only listened to the part you identified about desipramine. He does say it has some not great side effects but it also has a much higher chance of being effective against pain than duloxetine. That sounds very positive. Glad you found out about this and I hope you have good luck with it if you decide to get started on it. Meanwhile I am very hopeful the DRG stimulator is going to be a big help to you as well. Hank

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1 reply
lorirenee1 | @lorirenee1 | Jun 22, 2020
In reply to @jesfactsmon "Lori, I like this Ian Carroll guy, he speaks in a straightforward understandable way. I only..." + (show)
@jesfactsmon

Lori, I like this Ian Carroll guy, he speaks in a straightforward understandable way. I only listened to the part you identified about desipramine. He does say it has some not great side effects but it also has a much higher chance of being effective against pain than duloxetine. That sounds very positive. Glad you found out about this and I hope you have good luck with it if you decide to get started on it. Meanwhile I am very hopeful the DRG stimulator is going to be a big help to you as well. Hank

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@jesfactsmon Yes, Hank, Ian Caroll is so bright, but just plain speaking. I did get my doc to prescribe this drug. Look for my update on my DRG trial. I just posted it. Done with the trial, on to surgery, July 9......take care, and thanks for all of your kindess. Lori

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